It seems very likely that the original problem is an upstream bug in SANE. There are a few issues reported there specifically against the Canon LiDE 220 that sound very similar:

https://gitlab.com/sane-project/backends/-/issues/439
https://gitlab.com/sane-project/backends/-/issues/518

On 12/9/2020 8:22 AM, Philipp Klaus Krause wrote:
Summary: The situation improved somewhat, but is still far from perfect:

There is still an odd waiting time when starting to scan at 2400 or 4800
(at 1200 and below the scan starts nearly instantly, after less than
second). At 4800 colors ar wrong.

Once one of these problems appears, it affects all resolutions until
restarting xsane:
Having done a scan at 2400 or 4800, subsequent scans at lower
resolutions also have the waiting time at the start. Having done a scan
at 2400 or 4800, where black appeared as bordeaux, subsequent scans at
lower resolutions also have wrong colors.

You mentioned that you are using GIMP to launch xsane. The problem with the colors could be occurring there. Can we rule that out? What happens if you run "scanimage" from the command-line — does it produce an image with the correct colors?

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