itksnap is the only remain rdep of vtk6:

 sebastic@coccia:~$ dak rm -Rn vtk6
 Will remove the following packages from unstable:

libvtk6-dev | 6.3.0+dfsg2-8.1+b1 | amd64, arm64, armel, armhf, i386, mips64el, mipsel, ppc64el, s390x libvtk6-qt-dev | 6.3.0+dfsg2-8.1+b1 | amd64, arm64, armel, armhf, i386, mips64el, mipsel, ppc64el, s390x libvtk6.3 | 6.3.0+dfsg2-8.1+b1 | amd64, arm64, armel, armhf, i386, mips64el, mipsel, ppc64el, s390x libvtk6.3-qt | 6.3.0+dfsg2-8.1+b1 | amd64, arm64, armel, armhf, i386, mips64el, mipsel, ppc64el, s390x
       vtk6 | 6.3.0+dfsg2-8.1 | source

Maintainer: Debian Science Team <debian-science-maintain...@lists.alioth.debian.org>

 ------------------- Reason -------------------

 ----------------------------------------------

 Checking reverse dependencies...
 # Broken Depends:
 itksnap: itksnap [amd64 i386]

 # Broken Build-Depends:
 itksnap: libvtk6-dev

 Dependency problem found.

The maintainer has not responded to the RC bugs affecting itksnap (#1013152 & #1010549).

itksnap should be removed from Debian along with vtk6, or itksnap should be update to 4.0 which claims to support VTK 9:

"
 * Updated library references to ITK 5, VTK 9, and Qt 6
"

https://github.com/pyushkevich/itksnap/blob/v4.0.0/ReleaseNotes.md#version-400

Kind Regards,

Bas

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