Steve Dower added the comment:

> what's to stop the attacker from distributing their own interpreter that just 
> doesn't use AMSI?

AppLocker https://technet.microsoft.com/en-us/library/ee619725.aspx

(In short, restrict which executables can be run on a particular system by 
path/certificate/etc.)

Also a combination of ACLs and the fact that they may not be able to copy files 
onto the system directly anyway - see my post just before yours.

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue26137>
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