Hello, I'm new on Linux and in this list. My intention is to help sharing my experience making this target scanner to work on Linux from OpenSuSE 10.1 on x86-64 arch. Just in case, I wrote a small "how to" on: http://en.opensuse.org/Epson_Perfection_3490_Photo
Considering OpenSuSE already with Sane, the major steps are: 1. Check if usb hoplug recognized your usb scanner: Use command line "lsusb" to check. 2. Check if sane let snapscan be available: Uncomment snapscan in /etc/sane.d/dll.conf 3. Check if snapscan recognize the usb scanner: On OpenSuSE use YaST (Hardware/Scanner). Do not know how to do it on Ubuntu. 4. Check if snapscan.conf (on /etc/sane.d) pointing correctly to the target scanner firmware esfw52.bin. obs: You can get the firmware esfw52.bin installing iscan-firmware 1.18 rpm package (in this 1.18 version there are packages for i386, i586 and x86-64 arch). That was all for me. scanimage command line works and so xsane. Regards Marcio