[ccp4bb] Postdoctoral Research Associate – Biochemistry/Biophysics

[Myles, Dean A A]

The Diffraction Group in the Neutron Scattering Division (NSD) at Oak Ridge 
National Laboratory (ORNL) has an immediate opening for a postdoctoral 
Biochemist or Biophysicist to join a multi-disciplinary research team in 
development and application of paramagnetic labeling and proton polarization 
techniques for structure analysis. This project involves multi-task efforts in 
molecular biology, NMR, dynamic nuclear polarization (DNP) and macromolecular 
crystallography, and collaboration with computational scientists developing ML 
and AI tools for molecular simulation and analysis. As an ORNL postdoctoral 
fellow you will have access to state-of-the-art facilities for isotopic 
labeling, biophysical characterization and X-ray diffraction, as well as access 
to world class facilities for neutron diffraction and scattering, and molecular 
simulations. The position represents an excellent opportunity for you to 
develop your career and interact with leading scientists from around the world.

A link to the position advertisement can be found here:

https://jobs.ornl.gov/job/Oak-Ridge-Postdoctoral-Research-Associate-Structural-Biology%2C-Biochemistry-and-Biophysics-TN-37830/1155718000/




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[ccp4bb] Structural Biology Workshop, June 10-12 2024

[Myles, Dean A A]

Dear All,

We would like to bring to your attention  the 2024 Neutrons in Structural 
Biology workshop.  This workshop will highlight the need for next-generation 
instruments and toolsets for structural biology, with a focus on neutrons and 
other complementary techniques, and the development of integrated experimental 
and computational frameworks that connect them.



Neutrons in Structural Biology - Challenges & Opportunities,

June 10-12th 204

Sheraton Pentagon City Hotel, Arlington, VA.



For details and registration see: Neutrons in Structural Biology - Challenges 
and Opportunities (10-June 12, 2024): Overview * ORNL Neutron Sciences 
Conferences (Indico) (sns.gov)



The workshop will include a 1-day satellite training workshop (June 10, 2024) 
to educate graduate students and postdoctoral researchers in the application of 
neutron techniques in structural biology.
A limited numbers of travel awards are available to support graduate students 
and post-doctoral fellows attendance at the workshop (see link above)
The travel award application deadline is April 12, 2024.




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[ccp4bb] Postdoctoral Research Associate: Oak Ridge National Laboratory

[Myles, Dean A A]

Dear Colleagues,

The Diffraction Group in the Neutron Scattering Division (NSD) at Oak Ridge 
National Laboratory (ORNL) has an immediate opening for a Postdoctoral Research 
Associate in macromolecular crystallography and/or structural biology to 
investigate the structure and function of biological complexes involved in 
catalysis, membrane transport and light harvesting systems. You will join a 
multi-disciplinary research team that is developing and applying isotopic 
labeling and neutron diffraction and scattering techniques to understand and 
control the structure, function and dynamics of complex biological systems. As 
an ORNL postdoctoral fellow you will have access to state-of-the-art facilities 
for isotopic labeling, biophysical characterization and X-ray diffraction, as 
well as access to world class facilities for neutron diffraction and scattering.
Applicants should have received a Ph.D. in structural biology, protein 
chemistry, biophysics or related science field within the last five years and 
should have extensive experience  in biophysical characterization using 
diffraction or scattering techniques. Experience in protein expression, 
purification and crystallization is desired.

For informal enquiries please contact Dean Myles 
(myle...@ornl.gov)

For further details and to apply, please see link below:

https://jobs.ornl.gov/job/Oak-Ridge-Postdoctoral-Research-Associate-Structural-Biology-TN-37831/533212900/






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[ccp4bb] Postdoctoral Research Associate at Oak Ridge National Laboratory

[Myles, Dean A A]

Postdoctoral Research Associate: Protein Chemist/Structural Biologist

The Biology and Soft Matter Division at ORNL invites applications for a 
post-doctoral Protein Chemist or Structural Biologist to join its Biology and 
Biomedical Science group.

The successful candidate will join a multi-disciplinary research team 
investigating the development and application of paramagnetic labeling and 
proton polarization for structure-function analysis of biological complexes 
involved in cell-signaling, DNA repair and light harvesting systems. These 
projects will involve multi-task efforts in molecular biology, NMR, dynamic 
nuclear polarization and protein crystallography. As an ORNL postdoctoral 
fellow you will have access to state-of-the-art facilities for isotopic 
labeling, biophysical characterization and x-ray diffraction, as well as access 
to world class facilities for neutron diffraction and scattering.  The position 
represents an excellent opportunity for researchers to develop their careers 
and interact with leading scientists from around the world.

Qualifications. A Ph.D. degree in protein chemistry, structural biology or 
related discipline is required. The candidate should have a proven track record 
in molecular biology techniques including cloning, protein expression and 
purification, and in biophysical characterization using NMR/EPR or X-ray 
techniques.  Additional experience in expression and production of membrane 
proteins or in covalent modification of proteins with fluorophores or spin 
labels, would be a distinct advantage. The candidate should be self-motivated, 
have excellent interpersonal, communication and presentational skills and a 
demonstrated ability to interact effectively with staff at all levels within a 
multi-disciplinary team.


Questions:

Questions regarding this position can be directed to: Dean Myles 
(myle...@ornl.govmailto:myle...@ornl.gov)



For more information  see: http://www.ornl.gov/ornl/careers/postdocs



To apply: CLICK HERE TO APPLYhttp://goo.gl/wJwtzb

Re: [ccp4bb] Call for Proposals: IMAGINE, a New Neutron Crystallography Diffractometer

[Myles, Dean A A]

This should be your first highlight to NSF - and he should see it today/tomorrow

From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Meilleur, 
Flora
Sent: Thursday, May 23, 2013 3:54 PM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Call for Proposals: IMAGINE, a New Neutron Crystallography 
Diffractometer

IMAGINE, Neutron Crystallography Diffractometer
High Flux Isotope Reactor (HFIR), Oak Ridge National Laboratory
Call for proposals for experiments anticipated to run from August through 
December 2013

You are invited to apply for beam time on the neutron quasi-Laue diffractometer 
IMAGINE, at the High Flux Isotope Reactor. Proposal will be accepted via the 
web-based proposal system until NOON Wednesday, July 31, 2013.
This call is for experiments anticipated to run from August through December 
2013.

Please see the attached flyer for additional information. For technical 
information about the capabilities of IMAGINE go to 
neutrons.ornl.gov/imagine/http://neutrons.ornl.gov/imagine/ or contact Flora 
Meilleur, meille...@ornl.gov, or Andrey Kovalevsky, kovalevsk...@ornl.gov.

Flora Meilleur, Ph. D
Assistant Professor, Molecular and Structural Biochemistry
North Carolina State University
IMAGINE lead scientist, Neutron Sciences Directorate
Oak Ridge National Laboratory
Phone: 865-242-5747

[ccp4bb] Frontiers in Neutron Structural Biology Workshop - Important Dates

[Myles, Dean A A]

Frontiers in Neutron Structural Biology
Oak Ridge National Laboratory Spallation Neutron Source
April 16-18, 2013


REMINDER - Registration deadline soon approaching.
Deadline Dates: The deadline for application is March 15, 2013, unless you 
qualify for one of the following exceptions:
The application deadline can be extended to April 1, 2013 if:
* You are making your own travel arrangements and not requesting travel 
funds from workshop sponsors, and
* You have a current ORNL badge, and
* You are a U.S. citizen.
Application: Everyone attending the workshop must register.
PLEASE NOTE: Day 3 will focus on panel discussion and preparation of the 
workshop report. Panelists will include invited speakers and facility experts, 
but all participants are welcome to attend.
More information can be found at this link 
https://neutrons.ornl.gov/conf/frontier2013.




Frontiers in Neutron Structural Biology
Oak Ridge National Laboratory Spallation Neutron Source
April 16-18, 2013

This meeting will bring together scientists to discuss new opportunities for 
biomedical research at the two advanced neutron user facilities (SNS and HFIR) 
at the Department of Energy's (DOE) Oak Ridge National Laboratory (ORNL). Users 
now have access to some of the world's most intense neutron beamlines for 
studying the structure, function, and dynamics of complex biological systems. 
ORNL plans to establish and operate a biomedical neutron technology research 
center (BNTRC) that will integrate and develop neutron scattering technologies 
with high performance supercomputing and biomolecular synthesis and 
deuterium-labeling. Participants will identify new scientific challenges and 
lines of biomedical inquiry that will drive the development and integration of 
these leading-edge technologies. An important function of the BNTRC will be to 
provide training, access, and expert assistance in these technologies to 
biomedical researchers.

In a satellite meeting, the developers of the comprehensive software suite 
Phenix (http://www.phenix-online.org/)http://www.phenix-online.org/ for 
macromolecular structure determination will give a one-day workshop on the use 
of the software for macromolecular neutron crystallography (MNC). Participants 
are encouraged to bring a laptop for the afternoon tutorial session. MNC is in 
a period of expansion at the moment; in North America the number of beamlines 
suitable for MNC is expected to quadruple over the next year. This workshop 
will introduce current and future MNC users to the new experimental beamlines 
at ORNL and provide a tutorial for structure refinement using PHENIX and nCNS. 
New developments will be described that greatly enhance structure refinement. 
Participants will be given real X-ray and neutron (XN) data and will be taken 
through joint XN structure refinement of proteins.

Scholarships for attendance are available from:

 *   Joint Institute for Neutron Scienceshttp://jins.tennessee.edu/ for those 
attendees from EPSCOR states (Alabama, Alaska, Arkansas, Delaware, Hawaii, 
Idaho, Iowa, Kansas, Kentucky, Louisiana, Maine, Mississippi, Montana, 
Nebraska, Nevada, New Mexico, North Dakota, Oklahoma, Rhode Island, South 
Carolina, South Dakota, Tennessee, Utah, Vermont, West Virginia, Wyoming, the 
Commonwealth of Puerto Rico, and the Virgin Islands). For details, please visit 
http://jins.tennessee.edu/epscor/index.html for the application form and 
contact Hope Moore at hmoo...@utk.edumailto:hmoo...@utk.edu. EPSCoR 
fellowship is federally funded through DOE and is unable to provide travel 
support for individuals employed by DOE institutions.
 *   The ORAU Travel Grants 
Programhttp://www.orau.org/university-partnerships/faculty-student-programs/default.aspx
 provides up to $800 to facilitate travel by a faculty member from an ORAU 
Sponsoring or Associate Institution or Branch Campus. Visits can be to 
collaborate with researchers at ORNL, Y-12, ORAU laboratories or work sites, or 
another ORAU institution. To apply, visit the ORAU Members Universities 
pagehttp://www.orau.org/university-partnerships/members.aspx, find your 
school, and contact your member councilor, who can submit a proposal for travel 
funding to the ORAU University Partnerships Office through the Members 
Onlyhttp://www.orau.org/university-partnerships/members-only.aspx section of 
that site.

More information can be found at this link 
https://neutrons.ornl.gov/conf/frontier2013.

[ccp4bb] Frontiers in Neutron Structural Biology Workshop

[Myles, Dean A A]

Frontiers in Neutron Structural Biology, Oak Ridge National Laboratory, 
Spallation Neutron Source
April 16-18, 2013
This meeting will bring together scientists to discuss new opportunities for 
biomedical research at the two advanced neutron user facilities (SNS and HFIR) 
at the Department of Energy's (DOE) Oak Ridge National Laboratory (ORNL). Users 
now have access to some of the world's most intense neutron beamlines for 
studying the structure, function, and dynamics of complex biological systems. 
ORNL plans to establish and operate a biomedical neutron technology research 
center (BNTRC) that will integrate and develop neutron scattering technologies 
with high performance supercomputing and biomolecular synthesis and 
deuterium-labeling. Participants will identify new scientific challenges and 
lines of biomedical inquiry that will drive the development and integration of 
these leading-edge technologies. An important function of the BNTRC will be to 
provide training, access, and expert assistance in these technologies to 
biomedical researchers.

In a satellite meeting, the developers of the comprehensive software suite 
Phenix (http://www.phenix-online.org/)http://www.phenix-online.org/ for 
macromolecular structure determination will give a one-day workshop on the use 
of the software for macromolecular neutron crystallography (MNC). Participants 
are encouraged to bring a laptop for the afternoon tutorial session. MNC is in 
a period of expansion at the moment; in North America the number of beamlines 
suitable for MNC is expected to quadruple over the next year. This workshop 
will introduce current and future MNC users to the new experimental beamlines 
at ORNL and provide a tutorial for structure refinement using PHENIX and nCNS. 
New developments will be described that greatly enhance structure refinement. 
Participants will be given real X-ray and neutron (XN) data and will be taken 
through joint XN structure refinement of proteins.

Scholarships for attendance are available from:

 *   Joint Institute for Neutron Scienceshttp://jins.tennessee.edu/ for those 
attendees from EPSCOR states (Alabama, Alaska, Arkansas, Delaware, Hawaii, 
Idaho, Iowa, Kansas, Kentucky, Louisiana, Maine, Mississippi, Montana, 
Nebraska, Nevada, New Mexico, North Dakota, Oklahoma, Rhode Island, South 
Carolina, South Dakota, Tennessee, Utah, Vermont, West Virginia, Wyoming, the 
Commonwealth of Puerto Rico, and the Virgin Islands). For details, please visit 
http://jins.tennessee.edu/epscor/index.html for the application form and 
contact Hope Moore at hmoo...@utk.edumailto:hmoo...@utk.edu.
 *   The ORAU Travel Grants 
Programhttp://www.orau.org/university-partnerships/faculty-student-programs/default.aspx
 provides up to $800 to facilitate travel by a faculty member from an ORAU 
Sponsoring or Associate Institution or Branch Campus. Visits can be to 
collaborate with researchers at ORNL, Y-12, ORAU laboratories or work sites, or 
another ORAU institution. To apply, visit the ORAU Members Universities 
pagehttp://www.orau.org/university-partnerships/members.aspx, find your 
school, and contact your member councilor, who can submit a proposal for travel 
funding to the ORAU University Partnerships Office through the Members 
Onlyhttp://www.orau.org/university-partnerships/members-only.aspx section of 
that site.

More information can be found at this link 
https://neutrons.ornl.gov/conf/frontier2013.

[ccp4bb] Post-Doctoral Associate in Structural Biology

[Myles, Dean A A]

The Neutron Sciences Directorate (NScD) at Oak Ridge National Laboratory 
operates the High Flux Isotope Reactor (HFIR), the United States' highest flux 
reactor based neutron source, and the Spallation Neutron Source (SNS), the 
world's most intense pulsed accelerator based neutron source. Together these 
facilities operate 24 instruments for neutron scattering research, each year 
carrying out in excess of 1,000 experiments in the physical, chemical, 
materials, biological and medical sciences for more than 3,000 visiting 
scientists. HFIR also provides unique facilities for isotope production and 
neutron irradiation. To learn more about Neutron Sciences at ORNL go to: 
http://neutrons.ornl.gov.

The Biology and Soft Matter Division at Oak Ridge National Laboratory (ORNL) 
invites applications for a post-doctoral structural biologist or macromolecular 
crystallographer to join its Biology and Biomedical Science group.

The successful candidate will join a multi-disciplinary research team 
investigating the structure and function of biological complexes that are 
involved in cell-signaling, DNA repair and light harvesting systems. These 
projects involve multi-task efforts in molecular biology, protein 
crystallography, small-angle scattering and computational modeling. The 
position represents an excellent opportunity for researchers to develop their 
careers and interact with leading scientists from around the world. As an ORNL 
postdoctoral fellow you will have access to leading small angle neutron 
scattering and neutron diffraction facilities, biofermentation laboratories, 
and biophysical characterization laboratories, in addition to in house small 
angle X-ray scattering and X-ray diffraction instrumentation.

A Ph.D. degree in structural biology or a related field is required. The 
candidates should have a proven track record in molecular biology techniques 
including cloning, protein expression and purification, crystallographic 
analysis data and structure determination and refinement. Additional experience 
in small angle scattering and/or other biophysical characterization techniques 
would be a distinct advantage. The candidate should be self-motivated, have 
good interpersonal, communication and presentational skills and demonstrated 
ability to interact effectively with staff at all levels and to work within a 
multi-disciplinary team.

To find out more information and apply, please visit http://1.usa.gov/WJLxXO

Questions regarding this position can be directed to Dr. Dean Myles 
(myle...@ornl.gov).

[ccp4bb] 5 Post Doctoral 3 Research Assistant Positions in Structural Biology

[Myles, Dean A.]

 5 Post Doctoral  3 Research Assistant Positions in Structural Biology


 

The Center for Structural Molecular Biology (CSMB)
(http://www.csmb.ornl.gov) and the Spallation Neutron Source (SNS) of
Oak Ridge National Laboratory (ORNL) (http://www.ornl.gov) has immediate
openings for five Post Doctoral Research Associates and three Research
Assistants. Applications are sought from highly creative and motivated
individuals who will join interdisciplinary teams to work in the
following areas:

 

Post Doctoral Research Associate: Protein Structure, Function and
Dynamics We seek a Biophysicist, Physicist or Chemist to work on the
high-resolution X-ray and neutron analysis of protein structure and
dynamics. The successful candidate will have experience in all aspects
of experimental protein crystallography, especially high-resolution
analysis and computational modeling.  Experience in molecular dynamics
simulation would be an asset. Contact: Dr. Dean Myles, email:
[EMAIL PROTECTED] mailto:[EMAIL PROTECTED] ; Dr. Pratul Agarwal, email:
[EMAIL PROTECTED] 

 

Post Doctoral Research Associate: Bio-inspired Membrane Systems. We seek
a Biophysicist/Physicist interested in the interactions of bio-molecules
with natural membranes and synthetic bio-inspired membrane systems for
solar energy applications.  Previous X-ray or neutron scattering
techniques are highly desirable.  Contact: Dr. Hugh O'Neill, email:
[EMAIL PROTECTED]

 

Post Doctoral Research Associate: Virus Structure and Function. We seek
a Biophysicist/Biochemist or Physicist to work on Small Angle Neutron
Scattering (SANS) and neutron reflectivity analysis of virus structure
and function. The candidate should be proficient in conducting all
aspects of experimental scattering and analysis, data reduction and
modeling. Previous work in either neutron or X-ray scattering is
desirable. 

Contacts: Dr. Flora Meilleur, email: [EMAIL PROTECTED]
mailto:[EMAIL PROTECTED] ; Dr. Dennis Brown (North Carolina State
University), email: [EMAIL PROTECTED]


Post Doctoral Research Associate: Biopolymer Structure We seek a
Biophysicist, Physicist or Physical Chemist to work on the X-ray and 

neutron analysis of hierarchical structure in lignocellulosic materials.
Lignocellulose holds great potential as a future source of bio-fuel. The
successful candidate should demonstrate skills in experimental research,
with strong emphasis on mathematical or computational data analysis.
Contact:  Dr. Volker Urban, email: [EMAIL PROTECTED]

 

Post Doctoral Research Associate: Molecular Computational Modeling. We
seek a Biophysicist, Physicist, Chemist or Computational Scientist with
experience in applying computational methods to the study of biological
macromolecules and software development in C/C++ or another high-level
language. Experience in X-ray or neutron scattering or protein
crystallography is desirable, but not required. The research will entail
developing computational methods for building models of macromolecular
complexes that combine small-angle X-ray and neutron scattering with
data from other experimental methods including NMR, mutagenesis and
various spectroscopies.  Contact: Dr. William Heller, email:
[EMAIL PROTECTED]

 

Three Research Assistants in Molecular Biology and Protein Chemistry In
addition, we have openings for up to three Research Assistants to work
on expression, purification and crystallization of recombinant proteins
from bacterial and eukaryotic sources.  M.S. or B.S. in biochemistry,
molecular biology or a related discipline is required.  Contact: Dr.
Dean Myles, email: [EMAIL PROTECTED] mailto:[EMAIL PROTECTED] 

 

How to Apply:  

Qualified applicants may apply online at
https://www2.orau.gov/ORNL_POST/. AlL applicants will need to register
before they can begin the online application.   All applications must be
received by December 20, 2007. For complete instructions, on how to
apply, please see the instructions at
http://www.orau.gov/orise/edu/ornl/ornl-pdpm/application.htm
http://www.orau.gov/orise/edu/ornl/ornl-pdpm/application.htm . When
applying for this position, please reference the position title and
number. This appointment is offered through the ORNL Postdoctoral
Research Associates Program and is administered by Oak Ridge Associated
Universities (ORAU). This appointment is open to all qualified U.S. and
non-U.S. citizens without regard to race, color, age, religion, sex,
national origin, physical or mental disability, or status as a
Vietnam-era veteran or disabled veteran. 

 
Dean Myles
Center for Structural Molecular Biology
Oak Ridge National Laboratory
PO Box 2008; MS-6142
Oak Ridge, TN 37831
Phone:  865-574-5662
Fax:  865-574-8363