Postdoctoral position on scaffold protein assemblies in MAPK cell signalling
A 2-year postdoctoral position (with possible extension) is available from the 1st of June 2022 in the team of Dr. Malene R. Jensen at the Institute for Structural Biology (IBS) in Grenoble, France. The successful candidate will work on the structure and dynamics of scaffold proteins and study their interactions with kinases of the mitogen-activated protein kinase (MAPK) cell signalling pathways. We exploit a combination of X-ray crystallography and NMR spectroscopy. More information can be found on the team website: www.jensen-nmr.fr <http://www.jensen-nmr.fr/> Facilities The Institute for Structural Biology <http://www.ibs.fr/spip.php?lang=en> is located on the EPN science campus in Grenoble in close proximity to the European Synchrotron Radiation Facility (ESRF), the European Molecular Biology Laboratory (EMBL) Grenoble Outstation and the Institute Laue-Langevin (ILL). The IBS houses six high-field NMR spectrometers (3 x 600, 700, 850 and 950 MHz) and wetlab facilities for cloning, expression and purification of proteins. Access is facilitated to a number of state-of-the-art research platforms through Integrated Structural Biology Grenoble <https://www.isbg.fr/?lang=en>. Qualifications The ideal candidate holds a PhD in chemistry, biochemistry or biophysics (or related discipline) and has experience in protein expression and purification and a proven track-record in solution NMR spectroscopy and/or X-ray crystallography. To apply for this position, please send your CV, a motivation letter and the names of two referees to malene.ringkjobing-jen...@ibs.fr <mailto:malene.ringkjobing-jen...@ibs.fr> Recent relevant publications L. Mariño Pérez, F.S. Ielasi, L.M. Bessa, D. Maurin, J. Kragelj, M. Blackledge, N. Salvi, G. Bouvignies, A. Palencia, M.R. Jensen Nature (2022), 602, 695-700. <https://www.nature.com/articles/s41586-022-04417-6> Visualizing protein breathing motions associated with aromatic ring flipping K.K. Rasmussen, A. Palencia, A.K. Varming, H. El-Wali, E. Boeri Erba, M. Blackledge, K. Hammer, T. Herrmann, M. Kilstrup, L. Lo Leggio, M.R. Jensen Proc. Natl. Acad. Sci. U.S.A. (2020) 117, 20576-20585. <https://www.pnas.org/doi/10.1073/pnas.2005218117> Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage E. Delaforge, J. Kragelj, L. Tengo, A. Palencia, S. Milles, G. Bouvignies, N. Salvi, M. Blackledge, M.R. Jensen J. Am. Chem. Soc. (2018) 140, 1148-1158. <https://pubs.acs.org/doi/abs/10.1021/jacs.7b12407> Deciphering the dynamic interaction profile of an intrinsically disordered protein by NMR exchange spectroscopy J. Kragelj, A. Palencia, M. Nanao, D. Maurin, G. Bouvignies, M. Blackledge, M.R. Jensen Proc. Natl. Acad. Sci. (2015) 112, 3409-3414. <https://www.pnas.org/doi/10.1073/pnas.1419528112> Structure and dynamics of the MKK7-JNK signalling complex -- Dr. Malene Ringkjøbing Jensen Research Director CNRS Institut de Biologie Structurale 71, avenue des Martyrs CS 10090 38044 Grenoble CEDEX 9 France ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
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