RE: [NMusers] %RSE for IIV when expressed as %CV instead of variance

Thanks to Karam who retrieved the quote I mentioned from Stuart Beal. -- Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP mobile: NZ+64(21) 46 23 53 ; FR+33(6) 62 32 46 72 email: n.holf...@auckland.ac.nz<mailto:n.holf...@auckland.ac.nz> web

RE: [NMusers] %RSE for IIV when expressed as %CV instead of variance

gene.com> was bounced by the University of Auckland email server. This may be linked to the red warning shown below. -- Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP mobile: NZ+64(21) 46 23 53 ; FR+33(6) 62 32 46 72 email: n.holf...@auckland.ac.nz<mailto:n.h

RE: [NMusers] %RSE for IIV when expressed as %CV instead of variance

assumption that the uncertainty of the parameters is normal and therefore symmetrical. Best wishes, Nick -- Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP mobile: NZ+64(21) 46 23 53 ; FR+33(6) 62 32 46 72 email: n.holf...@auckland.ac.nz<mailto:n.holf...@auckland.ac.nz> web: http:

RE: [NMusers] Observed (yaxis) vs Predicted (xaxis) Diagnostic Plot - Scientific basis.

diagnostic plots and VPCs that do not show observed AND predicted percentiles belong in the bin. Best wishes, Nick -- Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP mobile:NZ+64(21)46 23 53 ; FR+33(6)62 32 46 72 email: n.holf...@auckland.ac.nz<mailto:n.holf...@auckland.ac

RE: [NMusers] Specify full OMEGA matrix for simulation

Hi Philip, An exact alternative would be to use this: $OMEGA BLOCK(2) FIX 0.078 0 0.02 $OMEGA BLOCK(1) FIX 0 Note – I have not tested this but if BLOCK(2) FIX works then BLOCK(1) FIX should work. Best wishes, Nick -- Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP mobile:NZ

[NMusers] RE: Off diagonals in $TABLE

file (unless that is the only way you know to get input into R). Best wishes, Nick -- Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP mobile:NZ+64(21)46 23 53 ; FR+33(6)62 32 46 72 email: n.holf...@auckland.ac.nz<mailto:n.holf...@auckland.ac.nz> web

RE: [NMusers] data

. 1 00001. 00.153846 Best wishes, Nick -- Nick Holford, Professor Emeritus Clinical Pharmacology, MBChB, FRACP mobile:NZ+64(21)46 23 53 ; FR+33(6)62 32 46 72 email: n.holf...@auckland.ac.nz

RE: [NMusers] Assessment of elimination half life of mAb

sensitive half-life' should be avoided because half-life only has a scientifically useful meaning for first-order processes that can be visualised as exponential curves. Life is more than PK -- its PKPD is when it gets interesting (and complicated). Best wishes, Nick -- Nick Holford, Professor

[NMusers] mpiexec exit code 1 even though NONMEM MPI run was successful

suppress the misleading entries in stderror.txt. Thanks in advance if you can throw any light on these queries. Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zea

[NMusers] Wings for NONMEM version WFN750 for NONMEM 7.5.0

to 4. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.holf...@auckland.ac.nz

RE: [NMusers] Random effect on ALAG between dose events

differences. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.

RE: [NMusers] Random effect on ALAG between dose events

differences. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.

RE: [NMusers] Negative concentration from simulation

n JH, Schellens JHM, et al. Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses. Pharmacology research & perspectives. 2015;3(2):10.1002/prp2.131 Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology &a

[NMusers] Advanced PKPD Course Sils-Maria 2020 Sunday March 29 through Friday April 3 - Early bird extended to 28 March

. Note: Early Bird registration has been extended to 28 March 2020. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 2

RE: [NMusers] How to calculate confidence interval (CI) and prediction interval (PI) of individual prediction (IPRED) in NONMEM

compartment at the same time and to multiple compartments at the same time. You have to specify a dosing record for each dose and each compartment. There may be an internal NONMEM limit but I am not aware of one. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology

RE: [FORGED] [NMusers] $FINEDATA

Hi Belo, I suspect you have tried to run this code using NM-TRAN and NONMEM. NM-TRAN does not know about the $FINEDATA record. You need to run this code using the finedata.exe in the NONMEM util directory. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology

[NMusers] Advanced PKPD Course Sils-Maria 2020 Sunday March 29 through Friday April 3 - Early Bird closing soon

. Note: Early Bird registration will close 24 Jan 2020. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(

[NMusers] Advanced PKPD Course Sils-Maria 2020 Sunday March 29 through Friday April 3

. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.holf...@auckland.ac.nz<mailto

[NMusers] Sheiner-Rowland Advanced PKPD Course Sils-Maria 2020 Sunday March 29 through Friday April 3

. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.holf...@auckland.ac.nz

RE: [NMusers] bootstrap

Hi Niurys, I don't see any reason why the bootstrap won't work. Its only the IDs that are selected randomly so the FLAGs will work just the same as in the full data set. Good luck, Nick -Original Message- From: owner-nmus...@globomaxnm.com On Behalf Of Niurys.CS Sent: Saturday, 11

[NMusers] RE: Using Microsoft MPI with NONMEM

Hi Bob, Thanks for these instructions. Any chance you could put all the files into one zip file so I don’t have to download each file one at a time? Or explain how I can get my browser (Google Chrome) to download whole directories rather than just files? Best wishes, Nick -- Nick Holford

RE: [NMusers] How to format output table as purely comma-separated file

Hi Bob, I agree with Sebastien. This would be a useful option and even better if it was user friendly option like FORMAT=CSV which also converted from scientific format to general format (Excel format names). Best wishes, Nick From: owner-nmus...@globomaxnm.com On Behalf Of Sebastien Bihorel

RE: [NMusers] VPCs confidence intervals?

& systems pharmacology. 2017;6(2):87-109. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46

[NMusers] RE: OFV or Diagnostic Plot ?? Which one rules...

http://holford.fmhs.auckland.ac.nz/ http://orcid.org/-0002-4031-2514 Read the question, answer the question, attempt all questions From: Singla, Sumeet K Sent: Wednesday, 13 February 2019 8:35 PM To: Nick Holford Cc: nmusers@globomaxnm.com Subject: Re: OFV or Diagnostic Plot ?? Which one rules... Dr. Holford, I d

[NMusers] RE: OFV or Diagnostic Plot ?? Which one rules...

Hi Sumeet, The OFV is often king. But what does the VPC look like? That is the gold standard. Diagnostic plots are equivalent to Rorschach blots. If you find a way to let us see the VPCs then we can all enjoy the view. Best wishes, Nick Holford NHG. The visual predictive check - superiority

[NMusers] Send your abstract to PAGANZ 2019 in Auckland NZ - 6th-9th February - FINAL DAYS

ogress or a finished project. Work in progress presentations are often interesting to everyone and can lead to useful collaborations. We look forward to seeing you all in Auckland, February 2019. PAGANZ Local Organising Committee Jacqueline Hannam Nick Holford Brian Anderson Sam Holford -- Nick H

[NMusers] Send your abstract to PAGANZ 2019 in Auckland NZ - 6th-9th February

ogress presentations are often interesting to everyone and can lead to useful collaborations. We look forward to seeing you all in Auckland, February 2019. PAGANZ Local Organising Committee Jacqueline Hannam Nick Holford Brian Anderson Sam Holford -- Nick Holford, Professor Clinical Pharmacolog

[NMusers] Send your abstract to PAGANZ 2019 in Auckland NZ - 6th-9th February

n work in progress or a finished project. Work in progress presentations are often interesting to everyone and can lead to useful collaborations. We look forward to seeing you all in Auckland, February 2019. PAGANZ Local Organising Committee Jacqueline Hannam Nick Holford Brian Anderson Sam H

[NMusers] Come to PAGANZ 2019 in Auckland NZ - 6th-9th February

ogress presentations are often interesting to everyone and can lead to useful collaborations. We look forward to seeing you all in Auckland, February 2019. PAGANZ Local Organising Committee Jacqueline Hannam Nick Holford Brian Anderson Sam Holford -- Nick Holford, Professor Clinical Pharmacolog

[NMusers] Come to PAGANZ 2019 in Auckland NZ - 6th-9th February

ogress presentations are often interesting to everyone and can lead to useful collaborations. We look forward to seeing you all in Auckland, February 2019. PAGANZ Local Organising Committee Jacqueline Hannam Nick Holford Brian Anderson Sam Holford -- Nick Holford, Professor Clinical Pharmacolog

RE: [NMusers] Context-free lexer for NM-TRAN

Hi Ruben, I wrote an empirical translator to convert NM-TRAN to the DDMoRe MDL. http://nmtran-to-mdl.mango-solutions.com/ It was written in awk. As far a I know there were no formal parser/lexers used with NM-TRAN as part of DDMoRe. Best wishes, Nick I assume building a parser for NM-TRAN was

RE: [NMusers] [Suggest] NONMEM adds UTF-8 support for csv files

# is the default. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.

[NMusers] Please help Winnie unsubscribe

From: Sohn, Winnie <w...@amgen.com> Sent: Monday, May 14, 2018 8:41 PM To: Nick Holford <n.holf...@auckland.ac.nz> Subject: RE: Using Root-finding techniques to find Cmax/Tmax Hi Nick, I have tried to unsubscribe multiple times to NMusers. Can you please help? Thanks, Winnie From

[NMusers] RE: Using Root-finding techniques to find Cmax/Tmax

Bob, Thanks for the zip file. And for the motivation to explore intro7.pdf – always something interesting to learn in the modelling world (unlike those stuck in the NCA doldrums). Nick From: Bauer, Robert <robert.ba...@iconplc.com> Sent: Monday, May 14, 2018 7:16 PM To: Nick Holford &

[NMusers] RE: Using Root-finding techniques to find Cmax/Tmax

at a time. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.

Re: [NMusers] Numerical integreaion and change in clearance over time

using analytical solution when clearance changes over time to an agency or a journal?  Can it be acceptable? Thanks, Paul -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auck

Re: [NMusers] Allometric scaling of renal clearance with estimated glomerular filtration rate

suggestion or discuss cons and pro's anytime! Sincerely, Rob -Oorspronkelijk bericht- Van: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] Namens Nick Holford Verzonden: woensdag 6 december 2017 20:06 Aan: nmusers@globomaxnm.com Onderwerp: Re: [FORGED] [NMusers] Allometr

Re: [FORGED] [NMusers] Allometric scaling of renal clearance with estimated glomerular filtration rate

l Pharmacist-Clinical Pharmacologist Radboudumc, Nijmegen, The Netherlands Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629. The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under

[NMusers] Third ANNOUNCEMENT - The Sheiner-Rowland Advanced Course in PKPD - Melbourne, Australia 2018

ttp://www.paganz.org>) will be held in the same location from 5^th to 7^th February.  This will require a separate registration and fee. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private

[NMusers] Second ANNOUNCEMENT - The Sheiner-Rowland Advanced Course in PKPD - Melbourne, Australia 2018

ttp://www.paganz.org>) will be held in the same location from 5^th to 7^th February.  This will require a separate registration and fee. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 9201

Re: [NMusers] Inherit past calculation of parameter in NONMEM

7, 1081 HV Amsterdam, The Netherlands. Email: t@amc.uva.nl <mailto:t@amc.uva.nl> / t@vumc.nl <mailto:t@vumc.nl> Mobile: +31 659738693 -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckl

[NMusers] Advanced PKPD: The Sheiner and Rowland Advanced Course in PKPD Lambertville 10-15 Sept 2017

come with a scientific hand calculator or notebook computer. Ability to understand and converse in English is essential. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland

[NMusers] WFN for NONMEM 7.4.0 - version 742

RMIN=2 /nmbs/now recognizes when NONMEM output listing file is not created and gives a more helpful error message. Bug fix for VPC to display observation scatterplots. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A

Re: [FORGED] [NMusers] RE: question about random seed for simulation

s of service available on request and accessible at http://www.sgs.com/en/Terms-and-Conditions.aspx -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand offic

Re: [FORGED] [NMusers] RE: question about random seed for simulation

-and-Conditions.aspx -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.holf...@auckland.ac.nz

Re: [NMusers] Objective function

reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835 -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Phar

Re: AW: [NMusers] $Error log transformed

Thanks! Katrin Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629. The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under file number 41055629. -- Nick Holford, Professor Clin

Re: [NMusers] Simultaneous pk model of 2 drugs

r disclosure of the contents of this message is not permitted and may be unlawful. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mo

[NMusers] WCoP 2016 - Final reminder - early bird registration closes in one week - Wednesday 15 June

FMKrWM9oK8rJLdY8SAJWYFjBgghKJq4Puf-2FYL-2FU0ZWfw7WdXyvLAbuNexLbSI-2FCVo3xtUi1xo-2BoKt5pC9AlYoJFyoWaWWw8U-2Bk3phceumtMHrcuO23LjgoHs8n8Hzfx6WvC0OHOz758RQjYIRqUUrnFuHv3KfMb7oN4KjUFUiR1Ybt> -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room

[NMusers] Understanding allometry

ative Medication Errors and Adverse Drug Events." _Anesthesiology_ *124*(1): 25-34. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-

[NMusers] WCoP 2016 Brisbane Aug 21-24 - Early Bird Registration Closes in 3 weeks (15 June)

rWUWBXBZ-2FOUOtPsZBzp9FfR43W3gARbCMKlvk-2FqLuIewzyDo9mEcVr4YDvApLD6DLO4UHIXmnT1epuVvLTFE-2FTQMEATCUxzz8HMHrOSbRR7liQ8lp7WCmK4OtzLWKVK-2Bf0RN6DtlhcMl7PmhXKFUKqDG4ZvUpuZaAQ5Eo4QfiBQBUCjOiyL2C-2FM1Ch4H> -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auck

Re: [NMusers] Time varying volume of distribution implementation

l Pharmacy Saarland University Campus C2 2 66123 Saarbrücken Germany Office: +49/681/302-70255 Mobile: +49/151/22739489 thorsten.l...@mx.uni-saarland.de www.clinicalpharmacy.me -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A U

Re: [NMusers] ASCO and pharmacometrics

rewith. Click http://www.merckgroup.com/disclaimerto access the German, French, Spanish and Portuguese versions of this disclaimer. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag

[NMusers] World Conference on Pharmacometrics 2016 - ORAL submission closing date is Monday 7 March 2016

Committee http://wcop2016.org/committees/ <http://wcop2016.org/committees/> -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobil

[NMusers] World Conference on Pharmacometrics 2016 - ORAL submission closing date is Monday 7 March 2016

Committee http://wcop2016.org/committees/ <http://wcop2016.org/committees/> -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobil

Re: [NMusers] NONMEM code verification

Bruxelles, Belgique -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 email: n.holf...@auckland.ac.nz

Re: [NMusers] unbalanced data set

your help very much! Best regards, Zheng -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 email: n.hol

[NMusers] WCoP 2016 -- World Conference on Pharmacometrics 21-24 August 2016, Brisbane, Australia

op2016.org/committees/ <http://wcop2016.org/committees/> -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23

[NMusers] Sheiner Rowland Advanced Course in PKPD Sils Maria 2016,Sunday April 3 through Friday April 8 - Early Bird Registration

. Ability to understand and converse in English is essential. *Tutors, Resources: *http://www.advancedpkpd.org/* ** Registration and Local Details:* http://www.pkworkshops.com/PKA-Wkshp2016.htm *Register BEFORE Friday 26th January 2016 for the reduced rate of CHF 4,455 Swiss Fr ** * -- Nick

Re: [NMusers] RE: Weight based dosing

and also to account for all other factors correlated with weight (e.g. age) in order to obtain true allometric exponents. The theory of allometry is well explained by West & Brown (2005). Best wishes, Nick Holford N, Heo YA, Anderson B. A pharmacokinetic standard for babies and adults. J Pharm S

Re: [NMusers] PRED for BLQ-like observations

! Pavel -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 email: n.holf...@auckland.ac.nz

Re: [NMusers] Incorporating standard deviation (SD) on fitted mean values

(the variance is defined in your data). I would probably describe the mean as a normal distributed variable, so: Y = IPRED + EPS(1)*REPSD/SQRT(NSUB) $SIGMA 1 FIX Kind regards, -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A Univ

Re: [NMusers] RE: Pediatric brain scaling

e immediately by reply email and destroy all copies of the transmittal. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobil

Re: [NMusers] Saving solution to differential equation from previous time point and carry over to next time point

ay to declare persistent variables such that my code would work as intended? Thank you Tommy Li -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Ze

[NMusers] World Conference on Pharmacometrics 2016 - Registration and Call for papers

Executive Committee and the WCoP 2016 Organizing Committee http://wcop2016.org/committees/ <http://wcop2016.org/committees/> -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Au

Re: [FORGED] [NMusers] Phsysiological model

87*(WT/WTstd)**0.75 The weights that will be investigated go from 30 kg up to 80 kg. It would also be very helpful if one can give me an explanation as to why or why not. Thanks Andre -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room

Re: [NMusers] How to account for M-M in the presence of KaKe constraint in PopPK model

capacity. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(7)80 48 55 50 email: n.holf...@auckland.ac.nz http

Re: [NMusers] $SIZES failed

-9882043 efax: 720-2946783 www.pharmaxresearch.com -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(7)80 48 55

Re: [NMusers] Population PKPD using hair drug concentration

can give references so that I can read. Thanks once again. Regards -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53

[NMusers] Applied Pharmacokinetics and Pharmacodynamics and Population Analysis with NONMEM. Santiago, Chile Aug 31-Sep 4 2015

their understanding, acquiring skills in the population analysis of PKPD data with NONMEM. Details of the Course can be found athttp://www.advancedpkpd.org/pkpd-nonmem-santiago/ http://www.advancedpkpd.org/pkpd-nonmem-santiago/ -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology

Re: [NMusers] RE: Standard errors of estimates for strictly positive parameters

). Thank you. buSp9xeMeKEbrUze -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ +64(21)46 23 53 email: n.holf...@auckland.ac.nz http

Re: [NMusers] RE: IIV on res error

birth so this model is obviously misspecified unless you only study neonates on the day of birth when GA is the same as PMA. Best wishes, Nick Holford N. Dosing in children. Clin Pharmacol Ther. 2010;87(3):367-70. Anderson BJ, Holford NHG. Tips and traps analyzing pediatric PK data. Pediatric

Re: [NMusers] A question about handling large-scale data

, Peking Union Medical College Hospital, Beijing, China M.P.: +86-18610966092 O.P.: +86-10-69158356 -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923

Re: [NMusers] Negative DV values

with something like the M3 likelihood method. Regards, Rupert Rupert Austin, PhD Senior Scientist BAST Inc Limited Holywell Park Ashby Road Loughborough, LE11 3AQ, UK *From:*owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Nick Holford *Sent:* 03 October

[NMusers] WFN for NONMEM 7.3.0 - version 735

to simulate data and wait until finished before starting Monolix estimation. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21

Re: [NMusers] Negative DV values

. Thank you in advance. Siwei -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ +64(21)46 23 53 email: n.holf...@auckland.ac.nz

Re: [NMusers] OMEGA matrix

this when you define blocks which are not linked in any way with another correlation (like the band matrices above) e.g. 1 1 1 1 1 1 0 0 0 1 0 0 0 1 1 You would specify this as two blocks for NONMEM like this: $OMEGA BLOCK(3) 1 1 1 1 1 1 $OMEGA BLOCK(2) 1 1 1 Best wishes, Nick -- Nick Holford

Re: [NMusers] OMEGA matrix

address for your career in the NHS and can be accessed anywhere -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ +64(21)46 23 53 email

[NMusers] Why are my posts not appearing on nmusers?

I sent two posts to nmusers this morning (NZ time). The first never showed up but the second one did. I tried sending the first post two more times and they did not appear on nmusers. This is a test post to see if all my posts are being blocked. -- Nick Holford, Professor Clinical Pharmacology

Re: [NMusers] Inflated random effects showed by VPC

into this? Has anyone encountered similar things before? I truly appreciate any comments or suggestions. Yu Graduate student in Clinical Pharmaceutical Science University of Iowa -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University

Re: [NMusers] NONMEM vs SPSS

in Pharmacology Selwyn College Cambridge CB3 9DQ Tel: +44 (0) 1223 761303 Email: gej1...@cam.ac.uk mailto:gej1...@cam.ac.uk Web: www.pdn.cam.ac.uk/staff/jarvis http://www.pdn.cam.ac.uk/staff/jarvis Twit: @GavinEJarvis -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical

Re: [NMusers] Fatal error: NM7.30+WFN

at (1) gfortran: internal compiler error: Aborted (program f951) ** This error is very similar to that Pavel reported on NM7.20+XPOSE several years ago. Does anyone know how to fix this error? Thanks, Masaki -- Nick

Re: [NMusers] call random: 372 R IN CALL RANDOM MAY NOT BE USED GLOBALLY IN ANOTHER BLOCK.

Pavel, The solution is to assign R to another variable. I've also re-structured your code to make things clearer (IMHO). $PK IF (ICALL.EQ.4) THEN ; only one ICALL.EQ.4 block is needed IF (NEWIND.NE.2) THEN CALL RANDOM(2,R) UNUM=R ; save R value in a new variable ENDIF IF

Re: [NMusers] call random: 372 R IN CALL RANDOM MAY NOT BE USED GLOBALLY IN ANOTHER BLOCK.

tried it on different computers. On Wed, Mar 26, 2014 at 06:33 PM, Nick Holford wrote: Pavel, The solution is to assign R to another variable. I've also re-structured your code to make things clearer (IMHO). $PK IF (ICALL.EQ.4) THEN ; only one ICALL.EQ.4 block is needed

Re: [NMusers] backward integration from t-a to t

at 07:48 PM, Nick Holford wrote: Pavel, Unless your drug is an alkylating agent the use of AUC will always be mechanistically wrong. I hope you also considered the possibility of disease progression (i.e. changing baseline) and also the possibility of changing C50 due

Re: [NMusers] backward integration from t-a to t

/mail2web myhosting.com - Premium Microsoft® Windows® and Linux web and application hosting - http://link.myhosting.com/myhosting -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg

Re: [NMusers] Transit Absorption Model in NONMEM

wondering what was going wrong. I appreciate your comments. Thanks! Siwei On Tue, Dec 10, 2013 at 1:22 PM, Nick Holford n.holf...@auckland.ac.nz mailto:n.holf...@auckland.ac.nz wrote: Xinting, You are correct. Negative simulated measurements occur when you have an additive

[NMusers] WFN for NONMEM 7.3.0 - version 731

and $THETAR records allowing reference to THETA parameters by name. Support for NESI grid submission. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090

Re: [NMusers] Getting rid of correlation issues between CL and volume parameters

, please notify us immediately by telephone and e-mail and destroy any and all copies of this message in your possession (whether hard copies or electronically stored copies). Thank you. buSp9xeMeKEbrUze -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg

Re: [NMusers] Reporting and handling values below the limit of quantification

. I guess I will play a bit with simulations and see how much this matters. Thank you, Paolo On 2013/11/11 21:42, Nick Holford wrote: Paulo, The note associated with my Slide 7 is not intended to be a current recommendation but is intended to show the history of ideas. Stuart Beal examined

Re: [NMusers] Reporting and handling values below the limit of quantification

fixing the additive component to 1/2BLQ is reasonable. Cheers, Rob On 2013/11/09 06:55, Nick Holford wrote: Paulo, I wish you luck in trying to do this. I also spend some time trying to persuade the people in your lab to do intelligent things with their measurements when I was in Cape Town. I

Re: [NMusers] Reporting and handling values below the limit of quantification

capacity. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ +64(21)46 23 53 email: n.holf...@auckland.ac.nz http

[NMusers] Re: question about sampling time

it was originally intended is strictly prohibited. If you have received this e-mail in error, please contact the sender and delete all copies. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019

Re: [NMusers] Change of NSIG or R matrix

in a single model building? If not, could you please explain this a little bit? Thank you in advance! Best Regards -- Xinting Wang -- Xinting -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503

Re: [NMusers] Change of NSIG or R matrix

Wang -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ +64(21)46 23 53 email: n.holf...@auckland.ac.nz http

Re: AW: Re: [NMusers] Parameter Estimation in IF Conditioning Statement

, copying or distribution is strictly prohibited. -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ +64(21)46 23 53 FR +33(7)85 36 84 99

Re: [NMusers] Time-varing covariate and renal function as a covariate

Message - From: Standing Joseph (GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST) joseph.stand...@nhs.net To: J.H.Proost j.h.pro...@rug.nl; Matt Hutmacher matt.hutmac...@a2pg.com; 'Nick Holford' n.holf...@auckland.ac.nz; 'nmusers' nmusers@globomaxnm.com Sent: Wednesday

Re: [NMusers] Time-varing covariate and renal function as a covariate

-Original Message- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Nick Holford Sent: Monday, September 02, 2013 12:16 To: 'nmusers' Subject: Re: [NMusers] Time-varing covariate and renal function as a covariate Matt, Thanks for your interest

[NMusers] WCoP 2016! Request for initial expression of interest to host

, Yonsei University Asia: Yusuke Tanigawara, Keio University Europe: Mats Karlsson, Uppsala University Europe: France Mentré, Université Paris Diderot, Chair of the WCoP Executive Committee North America: Holly Kimko, Janssen RD North America: Stacey Tannenbaum, Astellas Pharma Oceania: Nick Holford

Re: [NMusers] Time-varing covariate

special to treat this type covariates then? Thanks! Best regards, Siwei On Fri, Aug 23, 2013 at 1:10 PM, Nick Holford n.holf...@auckland.ac.nz mailto:n.holf...@auckland.ac.nz wrote: Siwei, I don't know why you think this complicated. Suppose you have age (AGE) as a covariate

  1   2   3   4   >