I had the same issue. Uninstalling 5.2.2 and them installing 5.3.3 worked.

On Saturday, November 19, 2022 at 8:03:57 PM UTC-5 ccord...@gmail.com wrote:

> Hi,
>
> It seems your Anaconda installation is corrupted, so it's better for you 
> to remove it and reinstall it.
>
>
> Cheers,
> Carlos
>
> El 18/11/22 a las 18:26, M Hagen escribió:
>
> Any response on this?
> I also cannot upgrade Spyder from 5.2.2. Attempting to upgrade in the base 
> env causes the install script to just hang due to some unknown conflict. It 
> was suggested that I install in a new conda environment. I tried making a 
> spyder533 named env. But I get a new error when I try to install *any* 
> package in this new env:
> "CondaSSLError: OpenSSL appears to be unavailable on this machine. OpenSSL 
> is required to download and install packages." 
>   
> I also tried running the reset Spyder script and uninstalling Anaconda and 
> reinstalling it. Both attempts brought no joy.
> I appear to be stuck.
> -Mark
>
> On Monday, November 7, 2022 at 10:33:16 PM UTC-6 thoma...@gmail.com wrote:
>
>> When I try to upgrade Spyder in Navigator, the upgrade doesn't finish. 
>> The only way I have gotten Sypder 5.3.3 is as a stand-alone.
>>
>> Is there a way to uninstall anaconda and all of its components, folders, 
>> shortcuts etc. in case my previous installations are causing problems? I've 
>> tried plain uninstall, but I'm always left with folders etc.
>>
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