The word "theory" in this thread/question has to be clarified better.
Jacob On Mon, Jan 9, 2012 at 1:27 PM, Tim Gruene <t...@shelx.uni-ac.gwdg.de> wrote: > -----BEGIN PGP SIGNED MESSAGE----- > Hash: SHA1 > > Hi, > > in my opinion the resolution limit of crystals from large complexes/ > membrane proteins is more likely due to lattice imperfections and > long-range disorder, and cold neither cold temperatures nor stronger > radiation sources would circumvent this problem. > > Tim > > On 01/09/2012 08:02 PM, Cale Dakwar wrote: >> In theory, no: sub-angstrom resolution can be obtained for any and all >> proteins, including membrane proteins, and for large complexes. In >> reality, it becomes technically very difficult to achieve; you would need >> ever-colder temperatures and ever-stronger irradiation sources. >> >> P.S. In theory, the only limit to describing the location of the atoms >> would be described by the heisenberg uncertainty principle. >> >> >> >> On Mon, Jan 9, 2012 at 1:15 PM, Theresa H. Hsu <theresah...@live.com> wrote: >> >>> Dear crystallographers >>> >>> A theoretical question - can sub-angstrom resolution structures only be >>> obtained for a limited set of proteins? Is it impossible to achieve for >>> membrane proteins and large complexes? >>> >>> Theresa >>> >> > > - -- > - -- > Dr Tim Gruene > Institut fuer anorganische Chemie > Tammannstr. 4 > D-37077 Goettingen > > GPG Key ID = A46BEE1A > > -----BEGIN PGP SIGNATURE----- > Version: GnuPG v1.4.10 (GNU/Linux) > Comment: Using GnuPG with Mozilla - http://enigmail.mozdev.org/ > > iD8DBQFPCz+YUxlJ7aRr7hoRAro2AKD502CdF5N3AK2Bb38hxhAey0nQagCg/GSB > gONh31woZI+cxJqEhSVZHjM= > =4B4D > -----END PGP SIGNATURE----- -- ******************************************* Jacob Pearson Keller Northwestern University Medical Scientist Training Program email: j-kell...@northwestern.edu *******************************************
