Dear users, Is it advisable to refine the occupancy of a ligand for a 2.0Ang data by approximately changing the values of occupancy based on its b-factor? After refinement, there were some negative densities appearing in some parts of the ligand, like at the centre of a pyrimidine ring, so I expected that the problem is with the occupancy. (the crystal was obtained by co-crystallisation method). Kindly provide some suggestions.
Thanking you With Regards Kavya -- This message has been scanned for viruses and dangerous content by MailScanner, and is believed to be clean.
