Dear all, I would appreciate if you could bring the following PhD position to the attention of appropriate candidates. Please apply online at https://www.psi.ch/pa/stellenangebote/1426
The Laboratory of Biomolecular Research at the PSI offers a PhD Project in Electron Crystallography: Structure of E3 Ubiquitin Ligase MuRF1 The group of Dr. Tim Gruene is looking for an ambitious candidate to advance the young field of 3D electron crystallography of biomolecular samples. The main goal of this project is the structure determination of MuRF1. MuRF1 is an E3 Ubiquitin ligase that binds the titin mechanosensor domain in the cytoskeleton. The level of MuRF1 is up regulated when muscle tissue is to be degraded, e.g. because of inactivation of the muscle, food reduction, but also due to aging or chronic diseases. Therefore MuRF1 is of great medical interest. This project will be carried out in collaboration with Prof. Olga Mayans, University of Konstanz, and nanoscale crystals are available. The Laboratory of Biomolecular Research is one of the leading institutes in the development of 3D electron diffraction of macromolecules. We focus on improving electron microscopes and data reduction methods for electron diffraction. The structure of MuRF1 will be one of the first new protein structures determined with 3D electron crystallography. As part of this project, training data from know proteins will be used to improve existing data collection and data processing strategies, and also to improve existing hardware components. We offer ======== The LBR has access to several state-of-the-art electron microscopes suitable for diffraction studies. The project will be carried out as part of a team of highly skilled and diverse members working together to improve existing hardware, and methods for data analysis. The PSI is the largest research centre for natural and engineering sciences within Switzerland. We perform cutting--edge research in the fields of matter and materials, energy and environment and human health. PSI is committed to the training of future generations. We offer an attractive work environment and provide an excellent platform for your future career. In addition to being a great platform for your future scientific career, PSI offers very attractive work conditions and competitive salaries. See https://www.psi.ch/pa/working-at-psi for more details. Your Skills =========== General biochemical and/ or chemical lab experience are required. The candidate should have experience in crystallographic structure determination and an interest in methods development. The candidate should have a curious mind and be open to combine technologies from several fields to dive into a very young field in macromolecular structure determination. At PSI, this collaborative project focuses on the development of electron crystallography with the goal to de-specialise it and open it as technology to other less specialised research groups. Application =========== Applications including names of two to three referees and possible start dates should be submitted online at https://www.psi.ch/pa/stellenangebote/1426 Please contact me for further inquiries. Kind regards, Tim Gruene -- -- Paul Scherrer Institut Dr. Tim Gruene - persoenlich - Principal Investigator Biology and Chemistry OFLC/102 CH-5232 Villigen PSI Phone: +41 (0)56 310 5297 GPG Key ID = A46BEE1A
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