Dear Daniel, I appreciate you for your really worthwhile comments that would be useful for other scientists in this field.
Thanks. Frank On Thu, Apr 26, 2018, 17:13 Daniel M. Himmel, Ph. D. < danielmhim...@gmail.com> wrote: > I skimmed your paper, and overall it looks like a good overview > of high-throughput protein crystallization. However, I was surprised > that no mention was made of Formulatrix Rock Maker software, > which is an excellent computer-aided graphical tool for designing > crystallization screens rapidly. This software works either as a > standalone > or in conjunction with the Formulatrix Formulator (which the paper DOES > mention), > for preparing crystallization solutions, and/or an integrated system for > storing crystal drops and automatically photographing them under a > microscope. > > A great deal of experience and knowhow on high-throughput > protein crystallization was accumulated by > such researchers as Wladek Minor, Steve Almo, Jeff Bonanno, > and others, with whom I had the privilege of working during the > waning years of the "Protein Structure Initiative" and "Enzyme > Function Initiative". The controversy of these projects stemmed > from the high expense of the robotic equipment that made them > possible, but the methodologies developed and lessons learned > may be useful for high-throughput protein crystallization both > in academia and industry. Hopefully the cost of the robotic equipment > will come down. > > -Daniel > > > On Thu, Apr 26, 2018 at 11:43 AM, Yibin Lin <yyb...@gmail.com> wrote: > >> Dear CCP4BB Community, >> >> I would like to comment you guy a review of the last five years of >> high-throughput protein crystallization screening that would be a >> magnificent help for all scientists that struggle with macromolecular >> crystallization. >> >> Please see attachment, as well as below: >> >> >> https://www.tandfonline.com/doi/full/10.1080/17460441.2018.1465924 >> >> Thanks. >> >> Kind regards, >> >> Frank Lin >> > >
