The Prehna Lab is looking to recruit an outstanding graduate student (MSc or PhD position) to join the Department of Microbiology at the University of Manitoba, Canada (https://home.cc.umanitoba.ca/~prehnag/).
Our lab studies how bacteria communicate with their hosts, how they communicate with each other, and how they communicate with other micro-organisms. Project: Quorum sensing in Streptococcus The supported graduate student position will study the natural defense mechanisms that Streptococcus pyogenes uses to defend itself from anti-bacterial peptides. S. pyogenes is a major human pathogen responsible for Strep. Throat and flesh-eating disease that uses quorum sensing to coordinate gene expression within a human host. This social coordination is responsible for the up-regulation of enzymes that modify the bacterial cell wall and cell membrane to resist toxic anti-bacterial peptides secreted by the human host and competing bacteria. This project is aimed at understanding the biochemistry and structural biology of these defense enzymes in S. pyogenes with the goal of designing novel antibiotics. Qualifications Applicants should possess s Bachelor’s degree in the life sciences or a related discipline, and be interested in both biochemistry and microbiology. Some experience in molecular biology as well as protein expression and purification is desired but not required. Training in protein purification, X-ray crystallography, and NMR spectroscopy will be provided. This project has the potential for training in cryo-EM. English language skills, the ability to work in a team, willingness to learn, and good organizational skills are required. Application Applications should include: 1. The applicant's CV 2. A one-page summary of their motivation for pursing graduate studies 3. Contact details for at least two references Please send application materials to: gerd.pre...@umanitoba.ca The starting dates are Fall 2020 or January 2021. The University of Manitoba (http://umanitoba.ca/) is located in Winnipeg, Manitoba and is Western Canada’s first University. The University has large core-group of structural biology and biochemical researchers between the departments of Microbiology (http://www.sci.umanitoba.ca/microbiology/) and Chemistry (The Manitoba Group in Protein Structure and Function), access to the Canadian Light Source synchrotron, and comprehensive molecular biophysics instrumentation (500 and 600 MHz NMR, in-house XRD, ITC, CD, DSC, nanoDSF, AUC, DLS, SEC-MALS, and MST). Winnipeg is also home to the National Microbiology Laboratory, a leader in infectious disease research and collaborator with the Department of Microbiology. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
