Public Dear all, I have been noticed that the link for application was not working a couple of days ago. It is back again. Please, use it if you are interested in applying! https://jobs.merck.com/us/en/job/R176608/Associate-Principal-Scientist-Computational-and-Structural-Chemistry/
Description of the position is as follows: We are seeking a creative, self-motivated structural biologist with exceptional interpersonal and problem-solving skills to join the Computational and Structural Chemistry (CSC) group in Kenilworth, NJ, USA. CSC is a diverse and inclusive team of more than 100 structural scientists, computational chemists, informaticians, mass spectrometrists, biophysicists, and protein scientists who employ state of the art capabilities to drive drug design. We are an integral arm of both discovery and process chemistry and collaborate seamlessly with teams around the globe to innovate and invent better molecules faster. We are looking for an accomplished structural biologist to support drug discovery through the generation and analysis of Cryo-EM atomic structures of therapeutically important protein targets. The successful candidate will join our growing CSC team and be responsible for all aspects of the structural biology process, from sample preparation and data collection through data processing and structure determination. The successful candidate will be capable of advancing their own work and that of other scientists that they oversee in the context of drug discovery projects goals; contribute to hypotheses generation related to chemistry project and derived from structural information; designing experiments required to test hypotheses or recommend decisions based on a wholistic understanding of the project. To achieve those goals, the candidate will have immediate access to an internal Krios G3i microscope equipped with a K3 and FFI, personal assisted collection and additional access to a variety of CROs that perform Cryo-EM work for our Company on a routine basis. At the same time, the structural scientist will establish a strong network of internal interactions across locations but also to leverage external collaborations to keep our team at the cutting edge of evolution in the Cryo-EM and structure based drug discovery fields. Consistently cited as a great place to work, our Company employs talented people who discover, develop, manufacture, and market a wide range of vaccines and medicines to address unmet medical needs. Each of us is joined by an extraordinary sense of purpose - bringing our Company's finest achievements to people worldwide. Our Company's Kenilworth campus is located within commuting distance from New York City. This proximity allows for close interactions with the quickly expanding Cryo-EM community in all specialized fields as well as the structural biology community at large, giving easy access to the latest developments in the field. Required Experience and Skills: * PhD degree in structural biology with a minimum of two (2) years of experience in an industrial setting (pharmaceutical or biotech company) * M.S. or B.S. in chemistry, biochemistry, biophysics or a related field with a minimum of seven (7) or a minimum of ten (10) years of experience in an industrial setting respectively. * Demonstrated Cryo-EM experience in sample preparation, image processing & structure determination for atomic resolution single particle Cryo-EM. * Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required. * Demonstrated potential to lead projects and collaborate with scientists outside of their field of expertise. * Ability to drive external scientific interactions by publishing in peer-reviewed journals, presenting in external scientific meetings and/or establishing external collaborations. * Demonstrated potential to manage and mentor other scientists in structural biology. * Ability to work effectively and flexibly within timelines. Preferred Experience and Skills: * Experience with structure determination of antigen:antibody complexes. * Experience with structure determination of small molecule protein complexes. * Experience with the application of hybrid structural techniques to answer biological questions. * Ability to manage multiple projects and subsequent prioritization. * Experience with CryoSPARC live data processing software. * Experience with biophysical and functional characterization methods (e.g. SPR, NMR, thermal shift and calorimetric assays) to guide construct design and optimization of solution conditions for successful structural outcomes. * Experience using computational tools for protein engineering and design. From: Gomez Llorente, Yacob Sent: Monday, April 25, 2022 8:01 AM To: CCP4BB@jiscmail.ac.uk Subject: Open position at Merck (NJ, USA) for a cryoEM/X-ray Structural Biologist Public Dear all, we keep hiring at Merck! Continuing with the impressive success of cryoEM at Merck we are hiring for our group in Kenilworth, looking for an structural biologist with cryoEM/Xray background and industry experience. The successful applicant will belong to the cryoEM unit at Kenilworth, NJ, and will have access to an internal Krios equipped with a K3 and FFI, personal assisted collections, a cryoEM dedicated GPU cluster and abundant external resources. Foreign applicants are welcomed! Apply at: https://jobs.merck.com/us/en/job/R176608/Associate-Principal-Scientist-Computational-and-Structural-Chemistry/ Please, feel free to reach out for any question at yacob.gomez.llore...@merck.com<mailto:yacob.gomez.llore...@merck.com> or by LinkedIn: https://www.linkedin.com/in/yacob-gomez-llorente-4b249376/ Best, Yacob Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth, New Jersey, USA 07033), and/or its affiliates Direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
