Having worked with a few, I'm pretty certain that there is no "best" framework 
(though I'm sure some fanboys will flame me for this).

If you simply want a way to have JavaScript <-> CF conversations easily and 
without a lot of coding, I think any of them will work. 

My personal lightweight favorite is mootools (http://demos.mootoools.net) 
because it is very small and super easy to use/learn, but YUI, 
Prototype/Scriptaculous and Dojo are much more feature complete and are 
excellent frameworks as well.

Good luck

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