The CAP has the following to say about this issue (in the FAQ section on HE= R2 testing): "The CAP Immu= nohistochemistry Committee does not advocate transferring formalin-fi= xed tissues into alcohol. There are no data to support the validity= of testing specimens processed in this manner, and there is a signif= icant risk that incompletely fixed tissues will be placed in alcohol prematurely and tissue fixation will be completed in alcohol. This = may be more deleterious to IHC testing than slightly prolonged formal= in fixation. Data are also lacking on testing specimens that have h= ad prolonged exposure to xylene (or xylene substitute). Finally, it= is considered unacceptable to leave fully processed tissues in heate= d paraffin for prolonged periods."
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