I tried some different microtomes (Leica, Microm, Thermo Shandon, Sakura), as sledge as rotary types. My choise is Leica RM2245. Leica RM2245 is semi automatic? and RM2255 or RM2265 are full automatic models. I like RM2245 because this model have a "rock" mode, when operator does for a section only 1/4 rotation. It is very ergonomic!
Shandon Finesse ME also have "rock" mode, but I have not happy with it. Leica RM series have only one disadvantage - two different type for disposable blade holder (for low and high profile, but not universal). Buy both type holders. RM2245 cheaper than 55 or 65. Series 2125 is the same as Microm 325. I do not try Leica Cool Clamp. Hope this help. Maxim Peshkov Russia, Taganrog. _______________________________________________ Histonet mailing list Histonet@lists.utsouthwestern.edu http://lists.utsouthwestern.edu/mailman/listinfo/histonet