Since processing is not the issue, first standardize fixation, eg 4-6 hours 
before processing or in the first reagent on processor. Change that first 
formalin every 200 blocks or so.  When well-fixed, small tissues will tolerate 
rapid processing. Finally, if your pathologists can read the slides and your 
immunostains work, then only make small changes. And ignore the CAP.

Steve A. McClain, MD


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