*Job opening for a postdoctoral position to join the Structural Motility
team at the Curie Institute Paris, France. *
The *Structural Motility *team is searching for *a post-doctoral fellow to
join a dynamic laboratory *directed by Anne Houdusse at the Curie Institute
(Paris Center).
We are looking for an *expert in structural determination via X-ray
crystallography or cryoEM studies. *The project aims to gain insights on
molecular motors, in particular for how their cellular role is defined and
how they can be targeted in the context of novel therapies against human
diseases. The position will also lead to the development of *chemical
biology tools and drug candidates. *Our team indeed innovate to investigate
and understand molecular mechanisms in cells.
By joining our team, the post-doctoral fellow will be given opportunities
to direct research for challenging and important biological questions
requiring cryoEM approaches and will increase his/her knowledge on the
cytoskeletal by functional and cellular studies. He or she will have
access to all the equipment and software necessary for solving X-ray and
CryoEM structures, including a brand new 200 kV Glacios electron microscope
equipped with a Falcon 4 camera at the Curie Institute.
*Our team studies the mechanism and function of force production by
molecular motors *and has made important discoveries on how force
generation can power cellular processes in human health and how mutations
in their function lead to disease. A multi-disciplinary approach that
combines structural biology (x-ray and cryoEM), chemical biology and cell
biology is being used in our studies. With such an approach, we decipher
how molecular motors produce force by visualizing yet unknown structural
states, or by understanding how their activity is regulated. We use
chemical biology and cell biology approaches to test insights from
structures. We also investigate and develop specific modulators of the
force generated by these motors (including compounds in phase 3 clinical
trials) to guide the development of new therapies.
We are looking to recruit and train a dynamic and motivated candidate who
is eager to gain independence and take the lead on one of our exciting
scientific projects. Experience in molecular dynamics or cell biology is a
plus.
If you are interested, please send a CV and a statement of research
interests and goals as well as three letters of recommendation from your
previous employers.
*Contact *: Anne Houdusse (anne.houdu...@curie.fr)
*Website* : Structural Motility Team
https://institut-curie.org/team/houdusse
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