To anyone who might be interested:

I have an opening in my group for a research assistant.  The work will consist 
of cloning and protein expression, primarily using bacteria and insect cells, 
as well as protein purification and crystallization.  I am ideally looking for 
someone with strong cloning skills and a good laboratory track record.  
Industrial experience is not necessary but won't hurt either.

Please note that this is a junior-level position, suitable for someone with 
either a bachelor's and 5+ years of relevant experience, or a master's and 2+ 
years.  I will NOT be considering anyone with a Ph.D. for this position.  The 
best way to apply for this job is to go via our company website: 
http://www.imclone.com/careers.php  My position is number 120367.

Here's the full job description.

GENERAL SUMMARY


We are seeking a highly motivated, independent person to work as an essential 
part of a drug discovery project team. The central duties of this position 
include cloning, protein expression in bacteria and insect cells, protein 
purification and biochemical assays. However, in a small group like this one, 
flexibility is essential since there are many things which need to be done. The 
candidate must have experience in mammalian or insect cell culture as well as 
protein expression and purification. The responsibilities of this position can 
expand to match the desires and abilities of the successful applicant. 
Candidates should have 3+ years of relevant laboratory experience and at least 
a BS (MS preferred) in biochemistry or a related discipline. Good oral and 
written communication skills are absolutely necessary, as is the ability to 
work with others as a team. Extensive experience in the areas necessary for the 
job is a plus, but not as important as intelligence and the desire and ability 
to learn new skills quickly.


ESSENTIAL DUTIES AND
RESPONSIBILITIES

Every effort has been made to identify the essential functions of this 
position. However, it in no way states or implies that these are the only 
duties you will be required to perform, nor is it intended to be such a listing 
of the skills and abilities required to do the job. The omission of specific 
statements of duties does not exclude them from the position if the work is 
similar, related, or is an essential function of the position.

1. Designing protein expression constructs for bacterial and baculovirus 
expression systems
2. Expressing soluble proteins in bacteria and insect cells
3. Purifying proteins on a scale of 5-50 mg using a wide variety of techniques, 
especially affinity and gel filtration chromatography
4. Protein crystallization, crystal manipulation, and other structural biology 
work



ESSENTIAL KNOWLEDGE,
SKILLS, EXPERIENCE


1. Extensive molecular cloning experience
2. Protein purification experience
3. Insect or mammalian cell culture experience
4. The ability to think analytically and work independently
5. Protein crystallization and related skills will be taught on the job

--
Matthew Franklin , Ph.D.
Senior Scientist, ImClone Systems,
a wholly owned subsidiary of Eli Lilly & Company
180 Varick Street, 6th floor
New York, NY 10014
phone:(917)606-4116   fax:(212)645-2054


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