: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
Hi,
I'm going to have to disagree with this approach. Lumping all specimens
into the same procedure (fixation/processing time) is in no way a step
toward individualized care that is so often discussed. Doing this ignores
the basic fundam
to
be entirely honest staining times in many cases. I fear you may be
oversimplifying the situation and calling it standardization.
All the best,
Amos
Date: Wed, 13 Oct 2010 08:05:27 -0700
From: "Jesus Ellin"
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
To: &
nice A; Joyce Cline;
>histonet@lists.utsouthwestern.edu
>Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
>
>
>
>How much time is the tissue in formalin prior to going in the processor?
>Your total time in formalin can not exceed 48 hr. And you will still
>
histonet@lists.utsouthwestern.edu
>Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
>
>
>
>How much time is the tissue in formalin prior to going in the processor?
>Your total time in formalin can not exceed 48 hr. And you will still
>need to validate your process i
A; Joyce Cline;
histonet@lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
How much time is the tissue in formalin prior to going in the processor?
Your total time in formalin can not exceed 48 hr. And you will still
need to validate your process if you
ssa; Phyllis Thaxton; Mahoney,Janice A; Mike Pence; Joyce
Cline; histonet@lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
OK I usually do not like to chime in on this, but here I go. How can a
true validation of a specific target be obtained if the wiggle ro
: Wed, October 13, 2010 9:39:21 AM
Subject: Re: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
Phyllis:
The time required in NBF is not 8 hours only, that is exactly what the
regulations are trying to avoid, i.e. incomplete fixation.
René J.
--- On Wed, 10/13/10, Phyllis Thaxton wrote
@lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
For the weekend, we have our processor set for 36 hours in formalin and
then a hold in 70%. This allows for complete fixation and cuts down on
prolonged time in 70%
From: Phyllis
al Message-
From: Kuhnla, Melissa [mailto:melissa.kuh...@chsli.org]
Sent: Wednesday, October 13, 2010 9:45 AM
To: Phyllis Thaxton; Mahoney,Janice A; Mike Pence; Joyce Cline;
histonet@lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2
: Kuhnla, Melissa; Mahoney,Janice A; Mike Pence; Joyce Cline;
histonet@lists.utsouthwestern.edu
Subject: Re: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
We run a weekend (Friday til Monday AM) breast run where the tissues
are in 10% NBF for 8 hours, then in 70% alcohol for 48 hours in
; Mahoney,Janice A; Mike Pence; Joyce Cline;
histonet@lists.utsouthwestern.edu
Subject: Re: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
We run a weekend (Friday til Monday AM) breast run where the tissues are in
10% NBF for 8 hours, then in 70% alcohol for 48 hours in order to complete
Phyllis:
The time required in NBF is not 8 hours only, that is exactly what the
regulations are trying to avoid, i.e. incomplete fixation.
René J.
--- On Wed, 10/13/10, Phyllis Thaxton wrote:
From: Phyllis Thaxton
Subject: Re: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
To: "K
From: "Kuhnla, Melissa"
To: "Mahoney,Janice A" ; Mike Pence
; Joyce Cline ;
histonet@lists.utsouthwestern.edu
Sent: Tue, October 12, 2010 12:02:32 PM
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
I disagree. Prolonged formalin f
: Tuesday, October 12, 2010 11:03 AM
To: Mahoney,Janice A; Mike Pence; Joyce Cline;
histonet@lists.utsouthwestern.edu
Subject: SPAM-LOW: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
I disagree. Prolonged formalin fixation (over 48 hrs), diminishes
signals
-Original Message
; histonet@lists.utsouthwestern.edu
Subject: SPAM-LOW: RE: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for
Her2 and ER/PR - Email found in subject
Yes, but they didn't include HER2 officially. Those guidelines are still to
come is my understanding.
And then there is documenting the "co
h
Sent: Tuesday, October 12, 2010 14:18
To: teri.hall...@midmichigan.org; janice.maho...@alegent.org; mpe...@grhs.net;
joyce.cl...@wchsys.org; histonet@lists.utsouthwestern.edu
Subject: RE: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and
ER/PR - Email found in subject
In the summ
...@wchsys.org; histonet@lists.utsouthwestern.edu
Subject: RE: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2
and ER/PR - Email found in subject
In the summer of this year, ASCO/CAP issued new guidelines for proper
handling of breast specimens to improve the accuracy of ER and PR
status
M-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR -
Email found in subject
Sorry Jan,
ASCO/CAP Guideline Recommendations for HER2 in Breast Cancer Article
Table 6. Sample Exclusion Criteria to Perform or Interpret a HER2 FISH Assay
Item #3 Tissue fixed for prolonged intervals i
27;; Joyce Cline; histonet@lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
Formalin fixation time does not impact the results of FISH as it does
IHC.
Jan M
Omaha
-Original Message-
From: Mike Pence [mailto:mpe...@grhs.net]
Sent: Tuesday, October 1
Thank you.
Jan
From: teri.hall...@midmichigan.org [mailto:teri.hall...@midmichigan.org]
Sent: Tuesday, October 12, 2010 11:57 AM
To: Mahoney,Janice A; mpe...@grhs.net; joyce.cl...@wchsys.org;
histonet@lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
From: histonet-boun...@lists.utsouthwestern.edu on behalf of Mahoney,Janice A
Sent: Tue 10/12/2010 12:05 PM
To: 'Mike Pence'; Joyce Cline; histonet@lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
Formalin fix
.edu] On Behalf Of Mahoney,Janice A
Sent: Tuesday, October 12, 2010 10:25 AM
To: 'Joyce Cline'; histonet@lists.utsouthwestern.edu
Subject: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
We have decided to reflex to FISH those breasts that do not fall within the
recommended forma
On Behalf Of
Mahoney,Janice A
Sent: Tuesday, October 12, 2010 10:25 AM
To: 'Joyce Cline'; histonet@lists.utsouthwestern.edu
Subject: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
We have decided to reflex to FISH those breasts that do not fall within
the recommended formalin f
t: Tuesday, October 12, 2010 10:25 AM
To: 'Joyce Cline'; histonet@lists.utsouthwestern.edu
Subject: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR
We have decided to reflex to FISH those breasts that do not fall within
the recommended formalin fixation time. We do work on Saturda
We have decided to reflex to FISH those breasts that do not fall within the
recommended formalin fixation time. We do work on Saturdays so it is only the
rare 3 day weekends that this comes into play.
Jan M
Omaha
-Original Message-
From: histonet-boun...@lists.utsouthwestern.edu
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