Using an update query with synchronize_session=False will generate a
single SQL statement that will be as efficient as possible.

Look at this example

http://stackoverflow.com/questions/270879/efficiently-updating-database-using-sqlalchemy-orm/270942

and docs

http://www.sqlalchemy.org/docs/05/reference/orm/query.html

It will be up to you then to make the query part clever enough to be
fast.

Let us know your solution, it is a common problem.


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