Annette, I found the following in a chapter by Troncoso, Crain, Sisodia, & Price in Khachaturian & Radebaugh's (1996) edited text entitled Alzheimer's Disease: Cause(s), Diagnosis, Treatment, and Care. Troncoso et al. indicate that plaques are extracellular (although they do not specify the location their diagram puts them in the synaptic cleft. They also indicate that the neurofibrilary tangles are located in the cell body with related cytoskeletal constituents located in the axon, cell body, and outside the cell body (e.g. neuropil threads & neurites). Hope this is helpful. Cheers, Rob Flint ------------------------------------------------------------- Robert W. Flint, Jr., Ph.D. The College of Saint Rose Department of Psychology 432 Western Avenue Albany, NY 12203-1490 Office: 518-458-5379 Lab: 518-454-2102 Fax: 518-458-5446 Behavioral Neuroscience Homepage: http://academic.strose.edu/academic/flintr/ Department of Psychology Homepage: http://academic.strose.edu/academic/psychology/index.htm > -----Original Message----- > From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]]On > Behalf Of Annette Taylor > Sent: Monday, May 01, 2000 11:04 AM > To: [EMAIL PROTECTED] > Subject: plaques & tangles and how to untangle a tangled web. > > > > I have two questions here: > one for the general audience and one for people with advanced knowledge > in Alzheimer's plaques & tangles: > > 1. I have been having students make presentations to the class > on special topics they selected to write a term paper about this > semester (human memory course). I believe that one of the students > gave incorrect information. > > I'd like suggestions on how to 'fix' the information the whole class > got without humiliating the student who gave the misinformation(it's > mmaybe not even humiliation, but maybe just making her feel just plain > old stupid?? I don't know, but you get the idea--I don't want her to > feel back, because, frankly, I have to post my second question just to > get the answer straight. > > 2. She made some very nice overheads of neurofibrillary tangles and > plaques but I think, based on my knowledge, that she located them > incorrectly. She located the plaques completely outside of the neurons > and the tangles within the cell bodies only. > > I have looked up in Carlson and in some web-downloaded materials one of > my colleagues has, exactly where these things might be located. It seems > like the plaques are deposited onto the axons, dendrites and synaptic > structures; the tangles themselves are not clearly defined but I had > always thought previously that they also were located within the > axons and dendrites more specifically, not the cell body, but I may > be wrong. > > I'd like to hear from anyone with knowledge whether I am correct or not, > or what the real story is; and does it matter?? > > thanks > annette > > Annette Taylor, Ph. D. > Department of Psychology E-mail: [EMAIL PROTECTED] > University of San Diego Voice: (619) 260-4006 > 5998 Alcala Park > San Diego, CA 92110 > > "Education is one of the few things a person > is willing to pay for and not get." > -- W. L. Bryan >
