Dear all,
I am working on modelling prednisone and prednisolone PPK in humans given a PO
dose of prednisone. Note that prednisone is converted to prednisolone during
the first-pass and prednisolone is converted back to prednisone (reversible
metabolism). I used a simple 2-cmt PK model (see
Hi,
I am working on a pop PK model to estimate PK parameters in pediatric and adult
patients. Pediatric study (n=20, age 6 yrs) has fewer samples (3) per subject
whereas the adult study (n=50, median age 20 yrs) has 12 samples per subject. A
two-compartment model best describes the data for
and Maturity
in Pharmacokinetics. Annu Rev Pharmacol Toxicol. 2008;48:303-32.
Chandrasekhar Udata wrote:
Hi,
I am working on a pop PK model to estimate PK parameters in pediatric
and adult patients. Pediatric study (n=20, age 6 yrs) has fewer
samples (3) per subject whereas the adult study (n=50
