Help, I'm still having issues with this.  I have a computer based GPO that was working and suddenly broke.  I have not gotten it fixed STILL. 

The .MSI is on a DFS share so that each site pulls the package down from a local fileserver.  I've checked permissions and all seems to be OK there.  Manually running the MSI works as advertised.
 
Here's my appmgmt.log:
 
04-29 07:20:06:048
Software installation extension has been called for foreground synchronous policy refresh.
The following policies are to be applied, flags are 1.
    CAM-DHQ-ALL Locations Security Policy (unique identifier {57D70152-BE34-4947-A896-B40111A07A42})
        System volume path = \\ccc.domainxyz.com\SysVol\ccc.domainxyz.com\Policies\{57D70152-BE34-4947-A896-B40111A07A42}\Machine
        Active Directory path = LDAP://CN=Machine,cn={57D70152-BE34-4947-A896-B40111A07A42},cn=policies,cn=system,DC=ccc,DC=domainxyz,DC=com
    CAM-DHQ-Computers Local Security Policy (unique identifier {6A1C9B35-C144-449D-ACA7-2F6FD31C73A1})
        System volume path = \\ccc.domainxyz.com\SYSVOL\ccc.domainxyz.com\POLICIES\{6A1C9B35-C144-449D-ACA7-2F6FD31C73A1}\MACHINE
        Active Directory path = LDAP://CN=Machine,cn={6A1C9B35-C144-449D-ACA7-2F6FD31C73A1},cn=policies,cn=system,DC=ccc,DC=domainxyz,DC=com
Set the Active Directory path to LDAP://CN=Class Store,CN=Machine,cn={6A1C9B35-C144-449D-ACA7-2F6FD31C73A1},cn=policies,cn=system,DC=ccc,DC=domainxyz,DC=com;LDAP://CN=Class Store,CN=Machine,cn={57D70152-BE34-4947-A896-B40111A07A42},cn=policies,cn=system,DC=ccc,DC=domainxyz,DC=com;.
Enumerating applications in the Active Directory for computer CAMDHQ31603 with flags 5.
The following applications were found in policy CAM-DHQ-ALL Locations Security Policy.
    Assigned application PatchLink Update Agent for Windows (flags a0005470).
Found 1 applications in policy CAM-DHQ-ALL Locations Security Policy.
Enumerating the managed applications which are currently applied to this user.
No managed applications are currently applied to this user.
Found 0 applications locally that are not included in the set of applications from the Active Directory.
Application PatchLink Update Agent for Windows from policy CAM-DHQ-ALL Locations Security Policy is set for installation because it is assigned to this computer policy.
Assigning application PatchLink Update Agent for Windows from policy CAM-DHQ-ALL Locations Security Policy.
Calling the Windows Installer to advertise application PatchLink Update Agent for Windows from script C:\WINDOWS\System32\appmgmt\MACHINE\{1da8aad1-08f5-40d4-9b18-68b8a6b126c8}.aas with flags 69.
The assignment of application PatchLink Update Agent for Windows from policy CAM-DHQ-ALL Locations Security Policy succeeded.
 
Calling the Windows Installer to install application PatchLink Update Agent for Windows from policy CAM-DHQ-ALL Locations Security Policy.
The install of application PatchLink Update Agent for Windows from policy CAM-DHQ-ALL Locations Security Policy failed.  The error was : %1603
 
Removing application PatchLink Update Agent for Windows from the software installation database.
Calling Windows Installer to remove application advertisement for application PatchLink Update Agent for Windows from script C:\WINDOWS\System32\appmgmt\MACHINE\{1da8aad1-08f5-40d4-9b18-68b8a6b126c8}.aas.
The removal of the assignment of application PatchLink Update Agent for Windows from policy CAM-DHQ-ALL Locations Security Policy succeeded.
 
Policy Logging for Software Management is attempting to log application PatchLink Update Agent for Windows from policy CAM-DHQ-ALL Locations Security Policy.
Failed to apply changes to software installation settings.  Software changes could not be applied.  A previous log entry with details should exist.  The error was : %1603
 
Software installation extension returning with final error code 1603.
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