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On Mon, 22 Oct 2001 [EMAIL PROTECTED] wrote:

> Hi everyone,
> 
> In Singapore, we define a dengue cluster (referring to an outbreak when
> dengue fever is spreading contagiously from one person to the next) as at
> least 2 cases (points) within 200 m of each other and within 3 weeks of
> incidence of each other. With about 2,000 cases so far this year, I have
> about about 80 clusters according to this definition.
> 
> However, I suspect that the occurence of some clusters (especially the ones
> with just 2 or 3 cases) may be by chance, instead of an actual disease
> transmission happening. How can I test this? Possibly, a Monte Carlo
> simulation of some kind will help. Is there any software out there that can
> help to do this? SATScan has got some promising functions, unfortunately it
> deals with areal or polygon data and not point data (I think).
> 
One possibility are the stkhat family of functions in Splancs, including
stmctest - a Monte-Carlo test of space-time clustering, see: Diggle, P.,
Chetwynd, A., Haggkvist, R. and Morris, S. 1995 Second-order analysis of
space-time clustering. Statistical Methods in Medical Research, 4,
124-136.

Software to run this in R (www.r-project.org) is contributed as a package
to be found on the same site (maintained by me), in S-PLUS at the original
site: http://www.maths.lancs.ac.uk/~rowlings/Splancs/. The article is not
very easy to get at, a further short description can be found in: Bailey,
T. C. and Gatrell, A. C. 1995, Interactive spatial data analysis. Longman,
Harlow, pp. 122-125.

A student from Thailand (Wutjanun Muttitanon <[EMAIL PROTECTED]>) also
drew my attention to an article I think using stkhat: Exploratory
space-time analysis of reported dengue cases during an outbreak in
Florida,Puerto Rico,1991-1992 Author : Amy C.Morrison and et al. Journal :
American Tropical Hygine ,Vol 58(3) pp287-298.

If you follow up this route using the splancs package for R, I'd be very
grateful for feedback to help improve its documentation and functionality.

Roger

-- 
Roger Bivand
Economic Geography Section, Department of Economics, Norwegian School of
Economics and Business Administration, Breiviksveien 40, N-5045 Bergen,
Norway. voice: +47 55 95 93 55; fax +47 55 95 93 93
e-mail: [EMAIL PROTECTED]
and: Department of Geography and Regional Development, University of
Gdansk, al. Mar. J. Pilsudskiego 46, PL-81 378 Gdynia, Poland.




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