Simone
 
Under the intrinsic hypothesis you can have a semi-variogram (bounded or unbounded) if the data is non-stationary. 
 
Generally we assume a stationary mean when calculating a semi-variogram to simplify the calculation. If the mean is not stationary, you have to include a drift or 'trend' in your calculation.
 
The data has to be stationary in the mean to have a covariance function simply because you have to subtract the mean to get a covariance. This is theory.
 
In practice you can always calculate the covariance, you just assume a constant mean. This does not guarantee that it is in any way meaningful.
 
If the mean is not stationary, you will get a parabola added to your 'real' semi-variogram graph. This is the universal sign of significant drift or trend. Your semi-variogram can be unbounded without going parabolic - see, for example, linear and power models.
 
If the variance of the data is non-stationary, you may still have intrinsic stationarity. The usual example used in the text books is a 'random walk' or Brownian motion. The test for intrinsic stationarity is obtaining a meaningful semi-variogram when you calculate it. You can also try jack-knifing - leave out some of your data and see if the semi-variogram still looks similar.
 
Isobel
http://www.kriging.com (under construction)
 
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