For the Postfix bit, I already have:
#=====================================================================
# Global antivirus/antispam pre-filter (Amavis)
#=====================================================================
smtp-amavis  unix -     -       n       -       5       smtp
    -o smtp_data_done_timeout=1200
    -o smtp_send_xforward_command=yes
    -o disable_dns_lookups=yes
    -o max_use=20
# SMTP interface for injecting mail into Amavis
127.0.0.1:10025 inet n    -    n    -    -  smtpd
    -o content_filter=smtp-amavis:[127.0.0.1]:10024
    -o smtpd_restriction_classes=
    -o smtpd_client_restrictions=
    -o smtpd_helo_restrictions=
    -o smtpd_sender_restrictions=
    -o smtpd_recipient_restrictions=permit_mynetworks,reject
    -o mynetworks=127.0.0.0/8
    -o smtpd_authorized_xforward_hosts=127.0.0.0/8
    -o strict_rfc821_envelopes=yes
    -o smtpd_error_sleep_time=0
    -o smtpd_soft_error_limit=1001
    -o smtpd_hard_error_limit=1000
#=====================================================================
# Mail re-injection (after pre-filtering)
#=====================================================================
127.0.0.1:10026 inet n    -    n    -    -  smtpd
    -o content_filter=
    -o smtpd_restriction_classes=
    -o smtpd_delay_reject=no
    -o smtpd_client_restrictions=permit_mynetworks,reject
    -o smtpd_helo_restrictions=
    -o smtpd_sender_restrictions=
    -o smtpd_recipient_restrictions=permit_mynetworks,reject
    -o smtpd_data_restrictions=reject_unauth_pipelining
    -o smtpd_end_of_data_restrictions=
    -o mynetworks=127.0.0.0/8
    -o smtpd_error_sleep_time=0
    -o smtpd_soft_error_limit=1001
    -o smtpd_hard_error_limit=1000
    -o smtpd_client_connection_count_limit=0
    -o smtpd_client_connection_rate_limit=0

So you removed the submission service?

A "usual" mail flow is "[email protected] -> smtpd(:25) -> content_filter(:10024) -> smtpd(:10025)", in which the latter 10025 does not have another Amavis content_filter.

Additional mail flows may be necessary such as for your DKIM use-case, e.g. "[email protected] -> smtpd(:submission) -> content_filter(:10026) -> smtpd(:10025)", so Port 10026 would have to be bound by Amavis, not Postfix.

As Matus has written, other constellations are possible.

Do I just duplicate the two sections starting 127.0.0.1, changing the ports but leave the first smtp-amavis section?
I don't see a use-case for smtpd(:10026) here.

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