Hi All,

I am following the code in the "Lab: CRMA v2 on 10K tumor data"
document to process 147 SNP6.0 arrays. 39 of these arrays are from
females and the rest are males. I am getting the following error
message at the end of circular binary segmentation step:

   Exception: Something is wrong with the data. Too many non-finite
values: 36890 (25.2% > 20.0%)
  at throw(Exception(...))
  at throw.default(sprintf("Something is wrong with the data. Too many
non-finite values: %d (%.1f%% >
  at throw(sprintf("Something is wrong with the data. Too many non-
finite values: %d (%.1f%% > %.1f%%)"
  at getRawCnData.CopyNumberChromosomalModel(this, ceList = ceList,
refList = rfList, chromosome = chro
  at getRawCnData(this, ceList = ceList, refList = rfList, chromosome
= chromosome, ..., estimateSd = F
  at extractRawCopyNumbers.CopyNumberChromosomalModel(this, array =
array, chromosome = chr)
  at extractRawCopyNumbers(this, array = array, chromosome = chr)
  at fit.CopyNumberSegmentationModel(this, ..., .retResults = FALSE,
verbose = verbose)
  at fit(this, ..., .retResults = FALSE, verbose = verbose)
  at plot.CopyNumberSegmentationModel(model, path = path, imageFormat
= "png", plotband = plotband, arr
  at plot(model, p

The sessionInfo is below:

> sessionInfo()
R version 2.11.1 (2010-05-31)
x86_64-pc-mingw32

locale:
[1] LC_COLLATE=English_United States.1252  LC_CTYPE=English_United
States.1252
[3] LC_MONETARY=English_United States.1252
LC_NUMERIC=C
[5] LC_TIME=English_United States.1252

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods
base

other attached packages:
 [1] RColorBrewer_1.0-2     DNAcopy_1.22.1
sfit_0.1.9             aroma.affymetrix_1.7.0 aroma.apd_0.1.7
 [6] affxparser_1.20.0      R.huge_0.2.0
aroma.core_1.7.0       aroma.light_1.16.1     matrixStats_0.2.2
[11] R.rsp_0.4.0            R.cache_0.3.0
R.filesets_0.9.0       digest_0.4.2           R.utils_1.5.3
[16] R.oo_1.7.4             R.methodsS3_1.2.1

loaded via a namespace (and not attached):
[1] splines_2.11.1

I am assuming that this error is to the presence of two genders but of
course I could be wrong. Can anyone provide an advice as to how to do
this properly to avoid getting the same error? Should I run the
"Vignette: Sex-chromosome bias-corrected reference signals from pooled
average?"

Thank you very much for your help...

Mete

-- 
When reporting problems on aroma.affymetrix, make sure 1) to run the latest 
version of the package, 2) to report the output of sessionInfo() and 
traceback(), and 3) to post a complete code example.


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