Generally its best to keep to a maximum of 2 PCI cards in a server as they each generate a lot of interrupts.
The IRQ distribution should be checked on a multi-processor system. I typically have 3 Sangoma cards in low end Xeon servers and there aren't any problems.

Recently, I needed to patch irqbalance to evaluate the numa node values because some somewhat older versions of CentOS (6.3, 6.4 initially) do not set certain links inside sysfs. If there is some interest, I could publish my small patch.

jg

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