I tried to clean and rebuild the entire thing, but this time running env 
LDFLAGS=-L/usr/local/Cellar CPPFLAGS=-I/usr/local/include ./configure before 
make all. Brew installs everything in /usr/local/Cellar.

I also used the avrdude.conf file from the SVN version:
/Users/hans/Downloads/SVN/avrdude/avrdude -Cavrdude.conf -vvv -patmega4808 
-cxplainedmini_updi -Pusb

Here's the output from the dtruss. It's so long I pasted everything on Gist 
instead of having it in an email: 
https://gist.github.com/MCUdude/4033c4cfdad2078845820d538e9d08f0 
<https://gist.github.com/MCUdude/4033c4cfdad2078845820d538e9d08f0>

BTW I don't own an Xplained Mini with an ATmega4808 soldered. I'm using a DIY 
Xplained Mini UPDI running on an Arduino Pro Micro. It's surprisingly reliable 
and stable!
The downside is that the firmware is not open source, and it only supports 
16-bit addressing. https://github.com/MCUdude/microUPDI 
<https://github.com/MCUdude/microUPDI>

Hans

> 14. des. 2021 kl. 21:00 skrev Joerg Wunsch <[email protected]>:
> 
> ./avrdude -C avrdude.conf -patmega4808 -cxplainedmini_updi >& logfile.txt

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