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Date: Feb 8, 2005 10:45 AM
Subject: Re: [balita-anda] Migrain
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Original Article:
http://www.mayoclinic.com/invoke.cfm?id=DS00120

Migraine

Overview

More than 28 million Americans - three times more women than men - suffer
from migraine, a type of headache that's often severe. Although any head
pain can be miserable, migraines are often disabling. In about 15 percent of
cases, these painful headaches are preceded by a sensory warning sign
(aura), such as flashes of light, blind spots or tingling in your arm or
leg. Migraines are also often accompanied by other symptoms, such as nausea,
vomiting and extreme sensitivity to light and sound. Migraine pain can be
excruciating and may incapacitate you for hours or even days.

Fortunately, migraine pain management has improved dramatically in the last
decade. If you've seen a doctor in the past and had no success, it's time to
make another appointment. Although there's still no cure, medications can
help reduce the frequency of migraines and stop the pain once it has
started. The right medicines combined with self-help remedies and changes in
lifestyle may make a tremendous difference for you.


Signs and symptoms

A typical migraine attack produces some or all of these signs and symptoms:

  a.. Moderate to severe pain - 60 percent of migraine sufferers feel pain
on only one side of their head, while 40 percent experience pain on both
sides
  b.. Head pain with a pulsating or throbbing quality
  c.. Pain that worsens with physical activity
  d.. Pain that hinders your regular daily activities
  e.. Nausea with or without vomiting
  f.. Sensitivity to light and sound
When left untreated, migraines typically last from four to 72 hours, but the
frequency with which they occur can vary from person to person. You may have
migraine headaches several times a month or just once or twice a year.

Not all migraines are the same. Eighty-five percent of people suffer from
migraines without auras, which were previously called common migraines.
About 15 percent of adults have migraine headaches with auras, which were
previously called classic migraines. If you're in the second group, you'll
likely have auras about 15 to 30 minutes before your headache begins. They
may continue after your headache starts or even occur after your headache
begins. These may include:

  a.. Sparkling flashes of light
  b.. Dazzling zigzag lines in your field of vision
  c.. Slowly spreading blind spots in your vision
  d.. Tingling, pins-and-needles sensations in one arm or leg
  e.. Rarely, weakness or language and speech problems


Whether or not you have auras, you may have one or more symptoms of
premonition (prodrome) several hours or days before your headache actually
strikes, including:

  a.. Feelings of elation or intense energy
  b.. Cravings for sweets
  c.. Thirst
  d.. Drowsiness
  e.. Irritability or depression

Migraine symptoms in children
Migraines typically begin in childhood, adolescence or early adulthood and
may become less frequent and intense as you grow older. Children as young as
age 1 can have these headaches. In fact, an estimated 4 percent to 10
percent of children suffer from migraines. In addition to physical
suffering, severe headaches often mean missed school days and trips to the
emergency room, as well as lost work time for anxious parents.

Children's migraines tend to last for a shorter time - about one to three
hours. But the pain can be disabling and can be accompanied by nausea,
vomiting, lightheadedness and increased sensitivity to light. Migraine tends
to occur on both sides of the head in children, and visual auras are rare.
However, children often have premonition signs and symptoms, such as:

  a.. Yawning
  b.. Sleepiness or listlessness
  c.. A craving for foods such as chocolate, hot dogs, sugary snacks, yogurt
and bananas
Children may also have all of the signs and symptoms of migraine - nausea,
vomiting, increased sensitivity to light and sound - but no head pain. These
"abdominal migraines" can be especially difficult to diagnose.

The good news is that some of the same medications that are effective for
adults also work for children. Your child doesn't have to suffer the pain
and disruption of migraines. If your child has headaches, talk to your
pediatrician. He or she may want to refer your child to a pediatric
neurologist.


Causes

Although much about headaches still isn't understood, some researchers think
migraines may be caused by functional changes in the trigeminal nerve
system, a major pain pathway in your brain, and by imbalances in brain
chemicals, including serotonin, which regulates pain messages going through
this pathway.

During a headache, serotonin levels drop. Researchers believe this causes
the trigeminal nerve to release substances called neuropeptides, which
travel to your brain's outer covering. There they cause blood vessels to
become dilated and inflamed. The result is headache pain.

Because levels of magnesium, a mineral involved in nerve cell function, also
drop right before or during migraines, it's possible that low amounts of
magnesium may cause nerve cells in the brain to misfire.

Migraine triggers
Whatever the exact mechanism of headaches, a number of things may trigger
them. Common migraine triggers reported by some people include:
  a.. Hormonal changes. Although the exact relationship between hormones and
headaches isn't clear, fluctuations in estrogen and progesterone seem to
trigger headaches in many women with migraines. About 60 percent of women
with a history of migraines report headaches immediately before or during
their periods. Others report more migraines during pregnancy or menopause.
Hormonal medications such as contraceptives and hormone replacement therapy
also may worsen migraine headaches.
  a.. Foods. Certain foods appear to trigger headaches in some people.
Common offenders include alcohol, especially beer and red wine; aged
cheeses; chocolate; fermented, pickled or marinated foods; aspartame;
caffeine; monosodium glutamate - a key ingredient in some Asian foods;
certain seasonings; and many canned and processed foods. Skipping meals or
fasting also can trigger migraines.
  a.. Stress. A period of hard work followed by relaxation may lead to a
weekend migraine. Stress at work or home also can instigate migraine
headaches.
  a.. Sensory stimulus. Bright lights and sun glare can produce head pain.
So can unusual smells - including pleasant scents, such as perfume and
flowers, and unpleasant odors, such as paint thinner and secondhand smoke.
  a.. Physical factors. Intense physical exertion, including sexual
activity, may provoke migraines. Changes in sleep patterns - including too
much or too little sleep - also can be a problem.
  a.. Changes in the environment. A change of weather, season, altitude
level, barometric pressure or time zone can prompt a migraine.
  a.. Medications. Certain medications can aggravate migraine headaches.

Risk factors

Four out of five people with migraines have a family history of migraine. If
both your parents have migraines, there's a 75 percent chance you will too.
If just one parent has migraines, you have a 50 percent chance of developing
migraines.

You also have a relatively higher risk of migraines if you're young and
female. In fact, women are three times more likely to have migraines than
men are. Headaches tend to affect boys and girls equally during childhood
but increase in girls after puberty.

If you're a woman with migraines, you may find that your headaches worsen
during menstruation. They may also change during pregnancy or menopause.
Sixty percent of women report improvement in their migraines later in
pregnancy, but others report that their migraines worsened during the first
trimester. If pregnancy or menstruation affect your migraines, your
headaches are also likely to worsen if you take birth control pills or
hormone replacement therapy (HRT).


When to seek medical advice

Migraines are a chronic disorder, but they're often undiagnosed and
untreated. If you experience signs and symptoms of migraine, track and
record your attacks and how you treated them. Then make an appointment with
your doctor to discuss your migraines and decide on a treatment plan.

If you don't have a treatment plan when migraine strikes, try
over-the-counter (OTC) medications such as ibuprofen (Advil, Motrin,
others), naproxen sodium (Aleve, Anaprox) or aspirin or other self-care
measures for a day or two. If you don't get relief, see your doctor. Just
don't give aspirin to children under 16 because of the risk of Reye's
syndrome, a rare but potentially fatal disease.

Even if you have a history of headaches, see your physician if the pattern
changes or your headaches suddenly feel different. See your doctor
immediately or go to the emergency room if you have any of the following
signs and symptoms, which may indicate another, more serious medical problem
such as a concussion:

  a.. An abrupt, severe headache like a thunderclap
  b.. A new severe headache that isn't just on one side of your head
  c.. Headache with fever, stiff neck, rash, mental confusion, seizures,
double vision, weakness, numbness or trouble speaking
  d.. Headache after a recent sore throat or respiratory infection
  e.. Headache after a head injury, especially if the headache gets worse
  f.. A chronic headache that is worse after coughing, exertion, straining
or a sudden movement
  g.. New headache pain after age 55
It's likely your headaches don't signal a serious medical condition. But in
a small number of cases, headaches may be a symptom of a blood clot or brain
tumor. They may also signal temporal arteritis, a rare, headache-related
condition that usually affects those over age 55 and may lead to blindness
or stroke if not treated.


Screening and diagnosis

If you have typical migraine headaches or a family history of migraines,
your doctor will likely diagnose the condition on the basis of your medical
history and a physical exam. But if your headaches are unusual, very severe
or sudden, your doctor may recommend certain tests to rule out other
possible causes for your pain.

You may have vision tests, a computerized tomography (CT) head scan or
magnetic resonance imaging (MRI) - a diagnostic imaging procedure that
combines a strong magnetic field, radio waves and computer technology to
produce clear images of your internal organs, including your brain. During
an MRI, you lie on a special table while detectors take measurements of your
body from multiple angles. A computer processes the collected data to
produce a three-dimensional representation of your head.

If your doctor suspects that an underlying medical condition such as
meningitis or subarachnoid hemorrhage is the cause of your headaches, he or
she may recommend a spinal tap (lumbar puncture). In this procedure, a thin
needle inserted between two vertebrae in your lower back extracts a sample
of cerebrospinal fluid (CSF) for laboratory analysis. The procedure takes
about 30 minutes. You may feel pressure while the fluid is extracted and
have a headache afterward because of a drop in CSF pressure. Lumbar puncture
isn't without other risks, including a small risk of infection.


Complications

Sometimes your efforts to control your pain cause problems. Nonsteroidal
anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others)
and aspirin may cause side effects such as stomach pain, bleeding and
ulcers, especially if taken in large doses or for a long period of time.

In addition, if you take over-the-counter (OTC) or prescription headache
medications more than two or three times a week or in excessive amounts, you
may be setting yourself up for a serious complication known as rebound
headaches. Although these drugs can give you temporary relief, they not only
stop relieving pain, but actually begin to cause headaches. You then use
more pain medication, which traps you in a vicious cycle. If you're caught
in the rebound headache trap, talk to your doctor.


Treatment

At one time, aspirin was almost the only available treatment for headaches.
Now there are drugs specifically designed to treat migraines. Several drugs
commonly used to treat other conditions also may help relieve migraines in
some people. All of these medications fall into two classes - those that
reduce or prevent migraines (preventive medications), and those that stop
pain once it has started (pain-relieving medications).

Choosing a preventive strategy or a pain-relieving strategy depends on the
frequency and severity of your headaches, the degree of disability your
headaches cause and other medical conditions you may have. You may be a
candidate for preventive therapy if you have two or more debilitating
attacks a month, if you use pain-relieving medications more than twice a
week, if pain-relieving medications aren't helping or if you have uncommon
migraines.

Some medications aren't recommended if you're pregnant or breast-feeding.
Some aren't used for children. Your doctor can help find the right
medication for you.

Pain-relieving medications
For best results, take pain-relieving drugs as soon as you experience
migraine signs or symptoms. It may help if you rest or sleep in a dark room
after taking them:

  a.. Nonsteroidal antiinflammatory drugs (NSAIDs). These medications, such
as ibuprofen (Advil, Motrin, others) or aspirin, may help relieve mild
migraines. Drugs marketed specifically for migraine, such as the combination
of acetaminophen, aspirin and caffeine (Excedrin Migraine), also may ease
moderate migraines, but aren't effective alone for severe migraines. If
over-the-counter medications don't help, your doctor may suggest a stronger,
prescription-only version of the same drug. If taken too often or for long
periods of time, NSAIDs can lead to ulcers, gastrointestinal bleeding and
rebound headaches.
  b.. Triptans. Sumatriptan (Imitrex) was the first drug specifically
developed to treat migraines. It mimics the action of serotonin by binding
to serotonin receptors and causing blood vessels to constrict. Sumatriptan
is available in oral, nasal and injection form. Injected sumatriptan works
faster than any other migraine-specific medication - in as little as 15
minutes -and is effective in 70 percent to 80 percent of cases. But
injections may be inconvenient and painful. Since the introduction of
sumatriptan, a number of similar drugs have become available, including
rizatriptan (Maxalt), naratriptan (Amerge), zolmitriptan (Zomig),
almotriptan (Axert), frovatriptan (Frova) and eletriptan (Relpax). These
newer agents provide pain relief within two hours in 60 percent to 91
percent of patients, have fewer side effects and cause fewer recurring
headaches. Side effects of triptans include nausea, dizziness and muscle
weakness and, rarely, stroke and heart attack.
  c.. Ergots. Drugs such as ergotamine (Ergomar) and dihydroergotamine
(D.H.E 45) and dihydroergotamine nasal spray (Migranal) help relieve pain.
These drugs may have more side effects than triptans.
  d.. Medications for nausea. Metoclopramide (Reglan) is useful for
relieving the nausea and vomiting associated with migraines, not the
migraine pain itself. It also improves gastric emptying, which leads to
better absorption and more rapid action of many oral drugs. It's most
effective when taken early in the course of your migraine or even during the
aura before your headache begins. Prochlorperazine (Compazine) and
chlorpromazine (Thorazine) also may relieve nausea but do not affect gastric
emptying.


Preventive medications
Preventive medications can reduce the frequency, severity and length of
migraines and may increase the effectiveness of pain-relieving medicines
used during migraine attacks. In most cases, preventive medications don't
eliminate headaches completely, and some can have serious side effects. For
best results, take these medications every day, as your doctor recommends:

  a.. Nonsteroidal anti-inflammatory drugs (NSAIDs). Regularly taking
over-the-counter NSAIDs such as ibuprofen (Advil, Motrin, others) and
naproxen sodium (Aleve, Anaprox) may reduce the frequency of migraines. If
these medications don't help, your doctor may suggest a stronger,
prescription-only version of the same drug. However, long-term use of these
medications can lead to ulcers and gastrointestinal problems. Talk to your
doctor before taking these medications regularly - even the nonprescription
varieties.
  a.. Cardiovascular drugs. Studies consistently show that beta blockers -
which are commonly used to treat high blood pressure and coronary artery
disease - can reduce the frequency and severity of migraines.
Calcium-channel blockers, another class of cardiovascular drugs, especially
verapamil (Calan, Isoptin), also may be helpful. In addition, recent studies
suggest that the antihypertensive medications lisinopril (Prinivil, Zestril)
and candesartan (Atacand) are useful migraine prevention medications.
Researchers don't understand exactly why all of these cardiovascular drugs
prevent migraines. Side effects can include dizziness, drowsiness or
lightheadedness. Beta blockers can also raise blood sugar levels and mask
symptoms of low blood sugar in people with diabetes.
  a.. Antidepressants. Certain antidepressants are good at helping prevent
all types of headaches, including migraines. Most effective are tricyclic
antidepressants such as amitriptyline (Elavil), nortriptyline (Pamelor) and
protriptyline (Vivactil). These medications may reduce migraines by
affecting the level of serotonin and other brain chemicals. You don't have
to have depression to take these drugs.
  a.. Antiseizure drugs. Although the reason is unclear, some antiseizure
drugs such as divalproex sodium (Depakote), valproic acid (Depakene),
topiramate (Topamax) and gabapentin (Neurontin), which are used to treat
epilepsy and bipolar disease, seem to prevent migraines. Taken in high
doses, however, these antiseizure drugs can cause side effects such as
nausea and vomiting, diarrhea, cramps, hair loss and dizziness.
  a.. Cyproheptadine (Periactin). This antihistamine specifically affects
serotonin activity. Doctors sometimes give it to children as a preventive
measure.
  a.. Botulinum toxin (Botox). Some people receiving Botox injections for
their facial wrinkles have noted improvement of their headaches. Some
researchers believe that Botox may work by soothing muscle tension in your
head or interfering with the neurologic changes that cause migraines.
Additional research is necessary.

Prevention

Whether or not you take preventive medications, you may benefit from
lifestyle changes that can help reduce the number and severity of migraines.
One or more of these suggestions may be helpful for you:

  a.. Avoid triggers. If certain foods seem to have triggered your headaches
in the past, eat something else. If certain scents are a problem, try to
avoid them. In general, try to establish a daily routine with regular sleep
patterns and regular meals.
  a.. Exercise regularly. Aerobic exercise - about 30 minutes three times a
week - reduces tension and can help prevent migraines. If your doctor
agrees, choose any aerobic exercise you enjoy, including walking, swimming
and cycling. Warm up slowly, however, because sudden, intense exercise can
cause headaches.
  a.. Reduce the effects of estrogen. If you're a woman with migraines and
estrogen seems to trigger or make your headaches worse, or if you have a
family history of stroke or high blood pressure, you may want to avoid or
reduce the amount of medications you take that contain estrogen. These
medications include birth control pills and hormone replacement therapy.
Talk with your doctor about the best alternatives or dosages for you.
  a.. Quit smoking. If you smoke, talk to your doctor about quitting.
Smoking can trigger headaches or make headaches worse.

Self-care

Self-care measures can help ease migraine pain. Try these headache helpers:

  a.. Keep a diary. A diary can help you determine what triggers your
migraines. Note when your headaches start, how long they last and what, if
anything, provides relief. Be sure to record your response to any headache
medications you take. Also pay special attention to foods you ate in the 24
hours preceding attacks, any unusual stress, and how you feel and what
you're doing when headaches strike. If you're under stress, tell your
doctor.
  a.. Try muscle relaxation exercises. Progressive muscle relaxation,
meditation and yoga don't require any equipment. You can learn them in
classes or at home using books or tapes. Or spend at least a half-hour each
day doing something you find relaxing - listening to music, gardening,
taking a hot bath or reading.
  a.. Get enough sleep, but don't oversleep. The average adult needs seven
to nine hours of sleep a night.
  a.. Rest and relax. If possible, rest in a dark, quiet room when you feel
a headache coming on. Place an ice pack wrapped in a cloth on the back of
your neck and apply gentle pressure to painful areas on your scalp.

Coping skills

Living with migraines is a daily challenge. Headaches can be both
incapacitating and unpredictable and may interfere with your job, your
relationships with family and friends, and your overall quality of life.
Although new treatments offer more options than ever for pain management,
you may still get disabling headaches. You may also occasionally feel
anxious or depressed. These options may help you cope:

  a.. Counseling. A counselor or therapist can teach you techniques for
managing stress and coping with pain. Family therapy may help the people in
your life understand more about migraines.
  a.. Support groups. Like many people with migraines, you may find that
these groups are a good source of useful information as well as support.
Group members often know about the latest medical treatments and self-care
or complementary remedies. Your doctor may put you in touch with a group in
your area. The American Council for Headache Education Web site also
provides referrals to support groups nationwide.
  a.. Balance. Try to balance the use of medications with regular exercise,
relaxation techniques, nutritious meals and adequate rest. Allow yourself at
least a half-hour every day for relaxation.

Complementary and alternative medicine

Nontraditional therapies may be helpful if you suffer from chronic headache
pain:

  a.. Acupuncture. In 1998, the National Institutes of Health (NIH) issued a
long-awaited statement on acupuncture. Among other benefits, NIH researchers
found that acupuncture may be helpful for headache pain. This treatment uses
very thin, disposable needles that generally cause little or no pain or
discomfort.
  a.. Biofeedback. Biofeedback appears to be especially effective in
relieving migraine pain. This relaxation technique uses special equipment to
teach you how to monitor and control certain physical responses, such as
muscle tension.
  a.. Massage. Although massage is a wonderful way to reduce stress and
relieve tension, its value in treating headaches hasn't been fully
determined. For people who have tight, tender muscles in the back of the
head, neck and shoulders, massage may help relieve headache pain.
  a.. Herbs, vitamins and minerals. There is some evidence that the herb
feverfew may prevent migraines or reduce their severity. A high dose of
riboflavin (vitamin B-2) also may prevent migraines by correcting tiny
deficiencies in the brain cells. Oral magnesium supplements may reduce the
frequency of headaches in some people, although studies don't all agree on
this issue. In addition, infusions of magnesium seem to help some people
during an acute headache, and they seem to relieve migraine pain in people
with magnesium deficiencies. Ask your doctor if these treatments are right
for you. Don't use feverfew if you're pregnant.
  a.. Cervical manipulation. There are no scientifically valid studies that
prove that chiropractic or other spine manipulation treatments are effective
in the treatment of migraine.


By Mayo Clinic staff

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