Untuk DIARE pd bayi>6 bln, dapat juga menggunakan GUANISTREP... ----- Original Message ----- From: "Ade Novita" <[EMAIL PROTECTED]> To: <[EMAIL PROTECTED]> Sent: Friday, October 22, 2004 9:56 AM Subject: [balita-anda] nifural lagi
> NIFURAL > GENERIK > Nifuroksazida. > INDIKASI > Diare akut, kolopati spesifik & tidak spesifik, diare yang disebabkan > oleh E. coli pada anak-anak & orang dewasa. > KONTRA INDIKASI > Gangguan fungsi hati atau ginjal. > Hipertiroidisme, intoleransi Iodin. > PERHATIAN > Gangguan persarafan. > EFEK SAMPING > Neurotoksisitas berat, nyeri perut, diare, pigmen hijau pada lidah, > tinja & urin (air seni), gangguan otak. > KEMASAN > Sirup 250 mg/5 ml x 60 ml. > DOSIS > a.. Dewasa : 3 kali sehari 1-2 sendok teh. > a.. Anak-anak & bayi berusia lebih dari 6 bulan : 3 kali sehari 1 > sendok teh. > a.. Bayi berusia kurang dari 6 bulan : 2 kali sehari 1 sendok teh. > > PABRIK > Darya-Varia/Pharos Chemie. > > > Nifural (Nifuraxozide) derivat nitrofurantoin > Carcinogenesis, Mutagenesis, and Impairment of Fertility: > > Nitrofurantoin presented evidence of carcinogenic activity in female B6C3F1 > mice as shown by increased incidences of tubular adenomas, benign mixed > tumors, and granulosa cell tumors of the ovary. In male F344/N rats, there > were increased incidences of uncommon kidney tubular cell neoplasms, > osteosarcomas of the bone, and neoplasms of the subcutaneous tissue. In one > study involving subcutaneous administration of 75 mg/kg nitrofurantoin to > pregnant female mice, lung papillary adenomas of unknown significance were > observed in the F1 generation. > > Nitrofurantoin has been shown to induce point mutations in certain strains > of Salmonella typhimurium and forward mutations in L5178Y mouse lymphoma > cells. Nitrofurantoin induced increased numbers of sister chromatid > exchanges and chromosomal aberrations in Chinese hamster ovary cells but not > in human cells in culture. Results of the sex-linked recessive lethal assay > in Drosophila were negative after administration of nitrofurantoin by > feeding or by injection. Nitrofurantoin did not induce heritable mutation in > the rodent models examined. > > The significance of the carcinogenicity and mutagenicity findings relative > to the therapeutic use of nitrofurantoin in humans is unknown. > > The administration of high doses of nitrofurantoin to rats causes temporary > spermatogenic arrest; this is reversible on discontinuing the drug. Doses of > 10 mg/kg/day or greater in healthy human males may, in certain unpredictable > instances, produce a slight to moderate spermatogenic arrest with a decrease > in sperm count. > > Pregnancy, Teratogenic Effects: Pregnancy Category B. Several reproduction > studies have been performed in rabbits and rats at doses up to six times the > human dose and have revealed no evidence of impaired fertility or harm to > the fetus due to nitrofurantoin. In a single published study conducted in > mice at 68 times the human dose (based on mg/kg administered to the dam), > growth retardation and a low incidence of minor and common malformations > were observed. However, at 25 times the human dose, fetal malformations were > not observed; the relevance of these findings to humans is uncertain. There > are, however, no adequate and well-controlled studies in pregnant women. > Because animal reproduction studies are not always predictive of human > response, this drug should be used during pregnancy only if clearly needed. > > Non-teratogenic effects: Nitrofurantoin has been shown in one published > transplacental carcinogenicity study to induce lung papillary adenomas in > the F1 generation mice at doses 19 times the human dose on a mg/kg basis. > The relationship of this finding to potential human carcinogenesis is > presently unknown. Because of the uncertainty regarding the human > implications of these animal data, this drug should be used during pregnancy > only if clearly needed. > > > > > --------------------------------------------------------------------- > > DUKUNG situs Balita-Anda.Com sebagai Situs Terbaik Wanita & Anak 2004-2005 versi Majalah Komputer Aktif, dengan ketik: POLL ST WAN 2 > ke nomor 8811, selama 16 Okt sd. 30 Nov. 2004. > Raih sebuah ponsel SonyEricsson K500i, dua buah ponsel Nokia 3100 dan 10 paket merchandise komputerakt!f bagi para peserta polling yang beruntung. Satu nomor ponsel hanya berhak memberikan satu suara dukungan untuk tiap kategorinya. Polling ini berlaku untuk pelanggan Telkomsel, Indosat maupun Excelcom dengan tarif Rp 1.500. > > --------------------------------------------------------------------- > >> Kirim bunga, buket balon atau cake, klik,http://www.indokado.com/ > >> Info balita, http://www.balita-anda.com > >> Stop berlangganan, e-mail ke: [EMAIL PROTECTED] > > > --------------------------------------------------------------------- DUKUNG situs Balita-Anda.Com sebagai Situs Terbaik Wanita & Anak 2004-2005 versi Majalah Komputer Aktif, dengan ketik: POLL ST WAN 2 ke nomor 8811, selama 16 Okt sd. 30 Nov. 2004. Raih sebuah ponsel SonyEricsson K500i, dua buah ponsel Nokia 3100 dan 10 paket merchandise komputerakt!f bagi para peserta polling yang beruntung. Satu nomor ponsel hanya berhak memberikan satu suara dukungan untuk tiap kategorinya. Polling ini berlaku untuk pelanggan Telkomsel, Indosat maupun Excelcom dengan tarif Rp 1.500. --------------------------------------------------------------------- >> Kirim bunga, buket balon atau cake, klik,http://www.indokado.com/ >> Info balita, http://www.balita-anda.com >> Stop berlangganan, e-mail ke: [EMAIL PROTECTED]
