I'm sure your reviewer could offer additional advice as well, but first thought 
is are you downloading the data each time the package is run or each time a 
vignette or example is run?  Perhaps caching the file using  BiocFileCache 
would save some additional time (or be costly the first run but then be 
expedited on future runs)  See 
https://bioconductor.org/packages/devel/bioc/vignettes/BiocFileCache/inst/doc/BiocFileCache.html#cache-to-manage-package-data




Lori Shepherd

Bioconductor Core Team

Roswell Park Cancer Institute

Department of Biostatistics & Bioinformatics

Elm & Carlton Streets

Buffalo, New York 14263

________________________________
From: Bioc-devel <bioc-devel-boun...@r-project.org> on behalf of Nuno Agostinho 
<nunodanielagosti...@gmail.com>
Sent: Tuesday, October 9, 2018 10:51:56 AM
To: bioc-devel@r-project.org
Subject: [Bioc-devel] cTRAP: WARNINGS in package submission

Dear all,

I am the developer of cTRAP <https://github.com/nuno-agostinho/cTRAP>, a 
package that I recently submitted for approval to Bioconductor: 
https://github.com/Bioconductor/Contributions/issues/906 
<https://github.com/Bioconductor/Contributions/issues/906>.

The package makes use of ENCODE and L1000 datasets downloaded from the web and 
the examples for such functions include downloading some sample files. However, 
this makes R CMD check take more than 5 minutes and labels my package with 
WARNING. Should I simply mark the examples of "slow" functions with \dontrun? I 
do not think that is the optimal approach, but it is certainly the easiest 
solution to pass the 5 minute requirement of R CMD check.

Thank you for your time!

Best regards,
Nuno Agostinho
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