Hi Bioc,

A couple of Macx86_64 users have contacted me with this error when using 
DMRcate::rmPosReps(), which looks like it's propagating from a failure to load 
AnnotationHub:

Error: failed to load resource
  name: AH116484
  title: EPICv2manifest
  reason: error in evaluating the argument 'x' in selecting a method for 
function 'get': bad restore file magic number (file may be corrupted) -- no 
data loaded

Here is the sessionInfo() from one of them.

> sessionInfo()
R Under development (unstable) (2024-03-10 r86088)
Platform: x86_64-apple-darwin20
Running under: macOS Sonoma 14.5

Matrix products: default
BLAS:   
/System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib
LAPACK: 
/Library/Frameworks/R.framework/Versions/4.4-x86_64/Resources/lib/libRlapack.dylib;
  LAPACK version 3.12.0

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

time zone: Australia/Sydney
tzcode source: internal

attached base packages:
[1] grid      stats4    stats     graphics  grDevices utils     datasets  
methods   base

other attached packages:
[1] DMRcatedata_2.22.0   RColorBrewer_1.1-3   Gviz_1.48.0          
patchwork_1.2.0      ggrepel_0.9.5        data.table_1.15.4    plyr_1.8.9       
    DMRcate_3.0.2
 [9] ggthemes_5.1.0       GEOquery_2.72.0      Biobase_2.64.0       
limma_3.60.3         lubridate_1.9.3      forcats_1.0.0        stringr_1.5.1    
    dplyr_1.1.4
[17] purrr_1.0.2          readr_2.1.5          tidyr_1.3.1          
tibble_3.2.1         ggplot2_3.5.1        tidyverse_2.0.0      sesame_1.22.1    
    sesameData_1.22.0
[25] ExperimentHub_2.12.0 AnnotationHub_3.12.0 BiocFileCache_2.12.0 
dbplyr_2.5.0         GenomicRanges_1.56.1 GenomeInfoDb_1.40.1  IRanges_2.38.0   
    S4Vectors_0.42.0
[33] BiocGenerics_0.50.0  BiocManager_1.30.23

loaded via a namespace (and not attached):
  [1] splines_4.4.0                                       BiocIO_1.14.0         
                              bitops_1.0-7
  [4] filelock_1.0.3                                      cellranger_1.1.0      
                              R.oo_1.26.0
  [7] preprocessCore_1.66.0                               XML_3.99-0.16.1       
                              rpart_4.1.23
 [10] lifecycle_1.0.4                                     httr2_1.0.1           
                              edgeR_4.2.0
 [13] base64_2.0.1                                        MASS_7.3-61           
                              lattice_0.22-6
 [16] ensembldb_2.28.0                                    scrime_1.3.5          
                              backports_1.5.0
 [19] magrittr_2.0.3                                      minfi_1.50.0          
                              Hmisc_5.1-3
 [22] rmarkdown_2.27                                      yaml_2.3.8            
                              doRNG_1.8.6
 [25] askpass_1.2.0                                       DBI_1.2.3             
                              abind_1.4-5
 [28] zlibbioc_1.50.0                                     quadprog_1.5-8        
                              R.utils_2.12.3
 [31] AnnotationFilter_1.28.0                             biovizBase_1.52.0     
                              RCurl_1.98-1.14
 [34] nnet_7.3-19                                         
VariantAnnotation_1.50.0                            rappdirs_0.3.3
 [37] GenomeInfoDbData_1.2.12                             genefilter_1.86.0     
                              annotate_1.82.0
 [40] permute_0.9-7                                       
DelayedMatrixStats_1.26.0                           codetools_0.2-20
 [43] DelayedArray_0.30.1                                 xml2_1.3.6            
                              tidyselect_1.2.1
 [46] UCSC.utils_1.0.0                                    beanplot_1.3.1        
                              matrixStats_1.3.0
 [49] base64enc_0.1-3                                     illuminaio_0.46.0     
                              GenomicAlignments_1.40.0
 [52] jsonlite_1.8.8                                      multtest_2.60.0       
                              wheatmap_0.2.0
 [55] Formula_1.2-5                                       iterators_1.0.14      
                              survival_3.7-0
 [58] foreach_1.5.2                                       missMethyl_1.38.0     
                              tools_4.4.0
 [61] progress_1.2.3                                      Rcpp_1.0.12           
                              glue_1.7.0
 [64] gridExtra_2.3                                       SparseArray_1.4.8     
                              xfun_0.45
 [67] MatrixGenerics_1.16.0                               HDF5Array_1.32.0      
                              IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.1
 [70] withr_3.0.0                                         fastmap_1.2.0         
                              latticeExtra_0.6-30
 [73] rhdf5filters_1.16.0                                 fansi_1.0.6           
                              openssl_2.2.0
 [76] digest_0.6.35                                       mime_0.12             
                              timechange_0.3.0
 [79] R6_2.5.1                                            colorspace_2.1-0      
                              gtools_3.9.5
 [82] jpeg_0.1-10                                         dichromat_2.0-0.1     
                              biomaRt_2.60.0
 [85] RSQLite_2.3.7                                       R.methodsS3_1.8.2     
                              utf8_1.2.4
 [88] generics_0.1.3                                      rtracklayer_1.64.0    
                              prettyunits_1.2.0
 [91] httr_1.4.7                                          htmlwidgets_1.6.4     
                              S4Arrays_1.4.1
 [94] pkgconfig_2.0.3                                     
IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0 gtable_0.3.5
 [97] blob_1.2.4                                          siggenes_1.78.0       
                              XVector_0.44.0
[100] htmltools_0.5.8.1                                   ProtGenerics_1.36.0   
                              scales_1.3.0
[103] png_0.1-8                                           knitr_1.47            
                              rstudioapi_0.16.0
[106] tzdb_0.4.0                                          reshape2_1.4.4        
                              rjson_0.2.21
[109] nlme_3.1-165                                        checkmate_2.3.1       
                              curl_5.2.1
[112] org.Hs.eg.db_3.19.1                                 bumphunter_1.46.0     
                              cachem_1.1.0
[115] rhdf5_2.48.0                                        BiocVersion_3.19.1    
                              parallel_4.4.0
[118] foreign_0.8-86                                      AnnotationDbi_1.66.0  
                              restfulr_0.0.15
[121] reshape_0.8.9                                       pillar_1.9.0          
                              vctrs_0.6.5
[124] xtable_1.8-4                                        cluster_2.1.6         
                              htmlTable_2.4.2
[127] evaluate_0.24.0                                     bsseq_1.40.0          
                              GenomicFeatures_1.56.0
[130] cli_3.6.3                                           locfit_1.5-9.9        
                              compiler_4.4.0
[133] Rsamtools_2.20.0                                    rngtools_1.5.2        
                              rlang_1.1.4
[136] crayon_1.5.3                                        nor1mix_1.3-3         
                              mclust_6.1.1
[139] interp_1.1-6                                        stringi_1.8.4         
                              deldir_2.0-4
[142] BiocParallel_1.38.0                                 munsell_0.5.1         
                              Biostrings_2.72.1
[145] lazyeval_0.2.2                                      pacman_0.5.1          
                              Matrix_1.7-0
[148] BSgenome_1.72.0                                     hms_1.1.3             
                              sparseMatrixStats_1.16.0
[151] bit64_4.0.5                                         Rhdf5lib_1.26.0       
                              KEGGREST_1.44.1
[154] statmod_1.5.0                                       
SummarizedExperiment_1.34.0                         memoise_2.0.1
[157] bit_4.0.5                                           readxl_1.4.3

I notice that the same error happens on merida1 as well: 
https://bioconductor.org/checkResults/release/bioc-LATEST/DMRcate/merida1-checksrc.html.

Any suggestions or workarounds?

Best wishes,
Tim


===================

Tim Peters, PhD

Computational Scientist - Immunogenomics Laboratory
Conjoint Lecturer, St Vincent's Healthcare Clinical Campus
Garvan Institute of Medical Research
384 Victoria St., Darlinghurst, NSW, Australia 2010

E: t.pet...@garvan.org.au 
<https://gimr.garvan.unsw.edu.au/owa/t.pet...@garvan.org.au> | W: 
http://www.garvan.org.au<http://www.garvan.org.au/> | P: +612 9295 8325

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