*BioDiscovery **
29th March
2011*
* *Solutions for future
*
---------------------------------------------------------------------------------------------------------------------------------
*
**
*Gene Silencing and RNA Interference*
RNA interference (RNAi) is a mechanism that inhibits gene expression at the
stage of translation or by hindering the transcription of specific genes.It
is a way for cells to regulate which genes would be expressed. This amazing
phenomenon was first observed in petunias, when a scientist called Rich
Jorgensen introduced a pigment-producing gene under the control of a
powerful promoter. Instead of the expected deep purple color in the petunia,
the result was a mixture of variegated and white petunias.
RNAi targets include RNA from viruses and
transposons (significant for some forms of innate immune response), and also
plays a role in regulating development and genome maintenance. Small
interfering RNA strands (siRNA) are key to the RNAi process, and have
complementary nucleotide sequences to the targeted RNA strand. Specific RNAi
pathway proteins are guided by the siRNA to the targeted messenger RNA
(mRNA), where they "cleave" the target, breaking it down into smaller
portions that can no longer be translated into protein. A type of RNA
transcribed from the genome itself, microRNA (miRNA), works in the same way
Click to view a flash presentation of RNA
Interference on nature
http://www.nature.com/focus/rnai/animations/animation/ui_main.swf
Why do we need to shutdown the production of
some genes?Scientists have been interested in the ability to shut down
genes, so that observing the effect of turning down a gene can be observed
on an organism, giving clues about the function of the gene.
The ability to shut off the genes, may also
result in developing new treatments for diseases by turning down the harmful
protein producing gene.Today, the use of RNA interference for
biotechnological and therapeutic purposes is a hot research area. RNA
interference used to selectively suppress desired genes is a form of genetic
engineering. Imagine curing or making progress towards a cure for AIDS,
hepatitis, and the flu – all through selectively suppressing the expression
of viral genomes. Fully utilizing RNA interference, we might be able to
create cotton seeds without poison — they possess great amounts of protein
but natural cotton seeds are poisonous — tobacco without carcinogens, and
plants with extreme resistance to crop-destroying viruses. RNA interference
is a valuable method in the biotechnological toolbox which will continue
ushering in the biotech revolution for the 21st century.
*A nice article on RNAi can be found at:*
*http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html*
*Best of Luck*
------------------------------------------------------------------------------------------------------------
**
**
*BioDiscovery*
**
Solutions for future
Email: info.biodiscov...@gmail.com
DISCLAIMER: This e-mail contains proprietary information some or all of
which may be legally privileged. It is for the intended recipient only. If
an addressing or transmission error has misdirected this e-mail, please
notify the author by replying to this e-mail. If you are not the intended
recipient you must not use, disclose, distribute, copy, print, or rely on
this e-mail. Please consider the environment before printing this e-mail.
[image: cid:image003.jpg@01C9DEE6.C3CA7700]
We Can’t Run, Consider the Environment before printing. *********Stop Global
Warming**********
--
Regards
BioDiscovery Alerts,
BioDiscovery- Solutions for future
India
BioDiscovery-Solutions for future<http://biodiscovery.webstarts.com/index.html>
--
The value of a man or woman resides in what he or she gives;
Not in what he or she is capable of receiving.
Syed Asif Hussain Naqvi.
--
http://www.cbclickbank.com/bioinformatics/company.htm
List of the biotech company and address.
------------------------------------------------------------------------------------------
Biofriend Forum
http://www.biofriend.info/
=============================================
Meet Biofriend India Team Manager at Linkedin
http://in.linkedin.com/in/satishchauk
<<image005.jpg>>
