https://meetings.cshl.edu/courses.aspx?course=C-data&year=20
June 26 - July 9, 2020 Application & Materials Deadline: March 15, 2020 *Instructors:* Vince Carey, Harvard University Sean Davis, National Institute of Health *Keegan Korthauer, *University of British Columbia, Canada *Michael Love*, University of North Carolina, Chapel Hill *Tomas Rube*, University of California Merced Over the past decade, high-throughput assays have become pervasive in biological research due to both rapid technological advances and decreases in overall cost. To properly analyze the large data sets generated by such assays and thus make meaningful biological inferences, both experimental and computational biologists must understand the fundamental statistical principles underlying analysis methods. This course is designed to build competence in statistical methods for analyzing high-throughput data in genomics and molecular biology. *Topics Include:* - The R environment for statistical computing and graphics - Introduction to Bioconductor - Review of basic statistical theory and hypothesis testing - Experimental design, quality control, and normalization - High-throughput sequencing technologies - Expression profiling using RNA-Seq and microarrays - *In vivo* protein binding using ChIP-Seq - High-resolution chromatin footprinting with ATAC-Seq - DNA methylation profiling analysis - Integrative analysis of data from parallel assays - Representations of DNA binding specificity and motif discovery algorithms *Format:* Detailed lectures and presentations by instructors and guest speakers will be combined with hands-on computer tutorials. The methods covered in the lectures will be applied to example high-throughput data sets. *2019 Speakers:* *Brittany Adamson, *Princeton University, Princeton, NJ *Elana Fertig, *Johns Hopkins University, Baltimore, MD *Tuuli Lappalainen, *New York Genome Center & Columbia University, New York, NY *Karen Mohlke, *University of North Carolina, Chapel Hill, NC *Robert Patro, *Stony Brook University, Stony Brook, NYJune 26 - July 9, 2020 Application & Materials Deadline: March 15, 2020 -- Sean Davis, MD, PhD Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, MD 20892 https://seandavi.github.io/ https://twitter.com/seandavis12
