FierceBiotech Honors Xencor as One of the ``Fierce 15'' Biotech 
Companies of 2005 

Xencor, Inc., a company engineering superior biotherapeutics using 
its Protein Design Automation(R) technology, announced today that it 
has been selected as one of the "Fierce 15" for 2005 by 
FierceBiotech, an internationally recognized publication for the 
biotech industry covering the biotechnology and pharmaceutical 
markets. Xencor was chosen as one of the top emerging biotechnology 
companies for the company's innovative Protein Design Automation (PDA
(R)) technologies, including Xencor's XmAb(TM) technology that 
improves the potency of monoclonal antibodies. 


"The beauty of Xencor's work is that it focuses on the constant 
region of an antibody, redesigning a segment that helps it more 
effectively attack a target cell by improving an antibody's natural 
immune system recruitment," says John Carroll, of 
FierceBiotech. "Like the other swiftly developing companies on this 
year's Fierce 15 list, we'll be watching Xencor closely in the years 
ahead." 

"Xencor's PDA technology has allowed the company to generate an 
outstanding roster of industrial collaborators and grow an internal 
pipeline of biotherapeutics, with our lead candidate for the 
treatment of rheumatoid arthritis, DN-TNF, expected to enter human 
trials in 2006," said Bassil Dahiyat, President and CEO of 
Xencor. "Xencor is honored to be chosen for this distinction by 
FierceBiotech, a recognized leader in the industry for advancing an 
understanding of biotechnology companies and the life science 
community." 

The Fierce 15 celebrates the spirit of being "fierce" -- championing 
innovation and creativity, even in the face of intense competition. 
The list of Fierce 15 companies is available in today's issue of 
FierceBiotech and on the FierceBiotech Web site at 
http://www.fiercebiotech.com. 

About FierceBiotech 

FierceBiotech, an internationally recognized email newsletter for 
the biotech industry, provides more than 35,000 executives a must-
read briefing on the day's top stories in the biotech and 
pharmaceutical industries. Visit http://www.fiercebiotech.com for 
additional information. 

About Xencor 

Xencor, Inc., engineers biotherapeutics including protein 
therapeutic candidates and XmAb(TM) antibody drug candidates using 
its proprietary Protein Design Automation(R) technology platform. 
The company is internally advancing several therapeutics against 
biologically validated targets, including a protein therapeutic drug 
candidate for the treatment of arthritis and other rheumatic 
disorders and antibody candidates for the treatment of cancer. With 
multiple partners such as industry leaders Genentech and Roche, 
Xencor applies its suite of XmAb antibody Fc domains to improve 
antibody drug candidates for traits such as potency, affinity, and 
stability. Xencor also develops therapeutic protein variants in 
collaboration with major pharmaceutical partners. For more 
information, please visit www.xencor.com.



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