This is a first - as far as we know (and not the way
one wants to see one's residency hospital in the
news):

http://www.chron.com/cs/CDA/ssistory.mpl/metropolitan/2658521
"Three people have died from rabies transmitted by
organ transplants they received in Texas, the first
time the deadly disease has spread this way, U.S.
officials said Thursday. The officials said they'll
look into whether transplant organs should be screened
for rabies. But transplant experts said they doubted a
test could confirm rabies in the necessary time to
perform transplants...

"...In all, five people died in the incident -- four
in Texas, two of them Texans. It began when an
Arkansas man died in Texas and donated his liver,
kidneys and lungs. Surgeons performed transplants the
next day on three patients at Baylor University
Medical Center in Dallas and one patient at the
University of Alabama-Birmingham Hospital. 

"The three Baylor patients died of rabies a month to
six weeks after being released. The fourth patient,
who received two lungs, died of complications during
surgery.  The infections went undetected because the
donor had shown no symptoms of rabies, such as fever
or headaches, before dying of a brain hemorrhage at
Christus St. Michael Health Care Center in Texarkana.
It is not clear whether he died of rabies.

"Organ donors are tested for other diseases, including
hepatitis B and C, HIV/AIDS, and syphilis. Those tests
return results within six hours and are part of the
consent process.  Transplantations need to be done in
four hours for lungs, six hours for hearts and 24
hours for liver and kidneys...

"...Rabies is usually confirmed by autopsy, but there
is a test that typically returns results in 24 to 48
hours, said Dr. David Tweardy, a professor of
infectious diseases at Baylor College of Medicine in
Houston. He said it might be possible to accelerate
results from the test, which involves a scalpel biopsy
and a dye that lights up in the presence of the
virus...

"...Rabies is extremely rare in the United States,
killing only one or two people a year. There were no
human cases in 2001, the latest year for which figures
are available.  The disease, transmitted through an
animal bite or contact with the secretions of infected
animals, is almost always fatal if not treated before
symptoms begin. Early treatment consists of a shot of
immune plasma followed by five doses of a vaccine over
a 28-day period. 

"Symptoms may not appear for at least a month after a
bite; they include a stiff neck, seizures, and anxious
and disoriented states. The transplant victims
developed respiratory problems, lethargy, seizures and
neurological symptoms after being released.  The virus
was likely in the nerves of the transplanted organs,
said Cohen. It travels through the nervous system, not
the bloodstream. 

"The Arkansas donor probably was infected by a bat,
CDC officials said..." 

Debbi 
who worries more about hanta virus, given that her
cats are bringing home ~ one field mouse/day, and
hopes that her presumed bout of West Nile last year
means she can't get it again...


                
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