I'm having the same issue in a Guix System. After a pull and reconfigure
all the fonts in Xfce are messed up. After a lot of meddling and help from
#guix IRC, it seems installing font-dejavu and running fc-cache -rv after
that "solves" the problem. I have done the guix pull and reconfigure in
multiple Guix VMs, both with "sudo -i" and normally, just in case the
underlying system is out of date and causing these issues, but they all
lead to the same situation.

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