It seems possible (to boot from a CDROM in UEFI) with SysLinux:

https://wiki.syslinux.org/wiki/index.php?title=Isohybrid#UEFI



unclear if it is with GRUB too... Someone seems to say that System Resue CD do 
that



https://askubuntu.com/questions/1025656/how-do-i-boot-an-iso-file-from-my-drive-using-grub2-on-uefi-machines

suggest to use linuxefi and initrdefi Grub commands...

but I don't see those in the documentation... and GNU Mach is not a Linux...

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