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You should definitely check the data for twinning. just look at the
N(z) plot output by CCP4 (one of the graphs given out while converting
data to mtz; a sigmoidal shape for the acentric reflections indicate
twinning). you could check for twinning in CNS too. a separate section
with utilities to deal with twinned data is available in CNS. also try
Todd Yeates' twinning server.

hope this helps.

Sid.

-- 
Sudharsan Sridharan
Graduate Research Assistant
Dept. of Biochemistry/Biophysics
2128 TAMU
Texas A&M University
College Station, TX 77843-2128
USA.

Phone (work): 001-979-862-7639

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