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I can just about remember structures with a Wilson B as low as 55 ...
Phil
Flip Hoedemaeker writes:
>
> A protein should at least be partly ordered in order to get into the
> PDB. Obviously, proteins can be partially or totally disordered ("molten
> globules"), but I think it is impossible for a protein to be
> unstructured in the core while having a structured surface. So yes,
> disordered stretches in the PBD, or missing resdues (see REMARK 465 in
> the header) are always on the surface.
>
> About the highest B values in the PBD, you'd probably like to know what
> is the highest RELEVANT B value entry. This is hard to answer. I've
> deposited a structure with a Wilson B-value of 55, with the highest
> values (in an outside loop) well over 100. Other crystallographers might
> have omitted such a loop from the model, or even have lowered the
> occupancy to 0. Their is no specific policy I know of, but there has
> been a fairly long discussion on this BB on how to treat these
> disordered regions, browse the archives.
