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I would like to post this job ad on behalf of Professor Wucherpfennig. Please reply to him, not to me. Postdoctoral opportunity in Boston We have recently discovered that a T cell receptor from a patient with an autoimmune disease, multiple sclerosis, binds with a highly unusual topology to its self-peptide/MHC target (Nature Immunology 2005; 6: 490-6). The topology differed from all human T cell receptors specific for viral peptides, all of which bind to peptide/MHC with a very similar topology. These findings raise a number of interesting questions: Are altered topologies also observed for T cell receptors in other autoimmune diseases? What is the range of possible topologies? How do altered topologies modify early T cell receptor signaling events? We are recruiting a postdoctoral fellow to this project, with the goal of determining the structures of T cell receptors from other autoimmune diseases by X-ray crystallography. The candidate should have experience in protein expression and purification and preferably also have experience in structure determination. The Dana-Farber Cancer Institute and Harvard Medical School offer a stimulating intellectual environment in structural biology and immunology. To learn more about the research in the lab, visit our lab website at http://research.dfci.harvard.edu/tcell Please send resume and names/telephone/email of three references to Kai Wucherpfennig at [EMAIL PROTECTED] Michael Hahn PhD Dana Farber Cancer Institute D1410 44 Binney Street Boston MA 02115 phone: 617 582 8154 fax: 617 632 2662
