Hello Todd.
An experienced synthetic chemist is your best source of help here,
but otherwise have a look at these links.
And greasy molecules are no problem. Organic chemists crystalize them
like candy!
http://www.xray.ncsu.edu/GrowXtal.html
http://web.mit.edu/x-ray/cystallize.html
http://64.233.167.104/search?q=cache:jT4WIhISjqwJ:chem-tech.ucsd.edu/
Recharges/SMXF/multimedia/xtal%2520growing%2520summer%2520-%
2520Richard%2520Staples.ppt+crystallization+small+molecule+evaporation
+diffusion&hl=en&ct=clnk&cd=8
http://depts.washington.edu/eooptic/linkfiles/
Crystallisation_Techniques.doc
Good luck,
Jose.
**************************************
Jose Antonio Cuesta-Seijo
Cancer Genomics and Proteomics
Ontario Cancer Institute, UHN
MaRs TMDT Room 4-902M
101 College Street
M5G 1L7 Toronto, On, Canada
Phone: (416)581-7544
Fax: (416)581-7562
email: [EMAIL PROTECTED]
**************************************
On Jul 18, 2007, at 5:56 PM, Green, Todd wrote:
Hello all,
I am asking this question for a colleague(a chemist not a
crystallographer) who would like to crystallize a small molecule
(for clarification this is just the small molecule not a protein
complex). The compound is quite hydrophobic and is rather "greasy."
He has a free alcohol which could be a site of modification if this
would help. I have only worked with proteins and was hoping that
someone might be knowledgible and could point me in the direction
of some help(literature, websites, etc) that might aide as a ground
level tutorial on crystallization of small molecules, and if
possible more specifically crystallization of hydrophobic/"greasy"
small molecules.
Thanks in advance-
Todd Green
University of Alabama at Birmingham
