A position is available to work on the structural and functional studies of prokaryotic transcription machinery using X-ray crystallography as a tool (for the most recent results see Vassylyev et al., Nature, 2007a, 448, pp. 157-162; Vassylyev et al., Nature, 2007b, 448, pp. 163-168). More details on the lab research and organization are provided at the Web site:http://138.26.140.2/vassylyev/index.html. A successful candidate should have Ph.D. in biochemistry, molecular biology, or physics and should demonstrate considerable expertise and record in protein structure determination. Experience working with large macromolecular complexes, weakly diffracting crystals, and crystals affected by perfect merohedral twinning are of particular interest to this lab. Duties will include crystallization, data collection and processing, structure determination (using MR, MIR, MIRAS, MAD, SAD techniques), and refinement of the transcription intermediates formed by prokaryotic RNA polymera ses during the transcription cycle as well as the isolated transcription factors regulating different phases of transcription. The knowledge and experience in maintenance of the X-ray equipment, and experience in protein expression, purification and/or crystallization are desirable, but are not required. Compensation for this position is in accordance with NIH postdoctoral pay scale and will be pro-rated for experience. This position is available immediately until filled and offered initially for 1 year with possibility of extension for up to 4 years pending sufficient progress and productivity. To apply send a CV, letter of intent, names and contact information of three referees to [EMAIL PROTECTED]
