CALL FOR TARGETS: The CAPRI Experiment ----------------------------------------------------------------- A Critical Assessment of PRedicted Interactions http://capri.ebi.ac.uk
The community-wide CAPRI experiment is a blind test of the ability of protein docking algorithms to predict the mode of association of two proteins based on their three-dimensional structure. A CAPRI Round starts whenever an experimentalist offers an adequate target, and ends four to eight weeks later with the submission of predicted structures. A CAPRI target is a new, unpublished X-ray or NMR structure of a protein-protein complex, the components of which have a known 3D structure. CAPRI has been running for six years, during which 30 targets have been subjected to blind predictions. Special issues of Proteins dated July 1, 2003, Aug. 1, 2005 and Dec. 2007 describe the results. The experiment has greatly helped the 60-odd groups that participate in developing new methods and algorithms. Its continuation depends on experimentalist offering new targets. We call upon crystallographers who just completed, or hope to complete soon, the structure of a protein-protein complex, to make it available for prediction. If both components of the complex are already known, the predictors will be given the two PDB entry codes. If only one component structure is known, the other can be taken from the complex and communicated on a confidential basis. Four to eight weeks later, a complete set of coordinates should be forwarded to the CAPRI assessors. They will remain confidential until released by their authors.
The CAPRI Management Group: Kim Henrick (EBI Hinxton, UK), Joël Janin (Orsay, France), Lynn Ten Eyck (San Diego, CA), Michael Sternberg (London, UK), Sandor Vajda (Boston, MA), Ilya Vakser (Lawrence, KA), Shoshana Wodak (assessor, Toronto, Canada)
To submit a target to CAPRI, just contact Joël Janin at [EMAIL PROTECTED]
