Dear Yang,
Thanks for the reply. Both are P21. Point mutant. MR solved the mutant using native as a model.
What about the crystal contacts of the region that changed then? Is it different in "native" and "mutant" forms? Both space groups are the same, but what about the cell dimensions? Again, the packing here might be of importance. Have a look at the neighboring molecules and how the act on the varying region. Also, how different is this region? 1 angstrom? 10 angstrom?
BTW, what does HTH mean?
I don't know myself... everybody is using it, so I'm using it as well :) H(ope)T(his)H(elps). Kind regards. Leo ------------------------------------------------------------ Chavas Leonard, Ph.D. Research Associate ------------------------------------------------------------ Faculty of Life Sciences The University of Manchester The Michael Smith Building Oxford Road Manchester Lancashire M13 9PT ------------------------------------------------------------ Tel: +44(0)161-275-1586 e-mail: [EMAIL PROTECTED]
