A postdoctoral research position is available immediately to work on
challenging problems in structural biology:
Postdoctoral Researcher
Job ID: 21615
Division: Physical Biosciences
Date Opened: 3/28/2008
This postdoctoral position will study the structure and function of
macromolecular complexes and enzymes using X-ray crystallographic
methods. This position will be joint between the Center for Protein
Folding Machinery (proteinfoldingcenter.org) and the Joint BioEnergy
Institute (www.jbei.org). The biological systems to be studied will
include: Type-II chaperonins responsible for the refolding of unfolded
proteins in archeal and mammalian cells, Glycosyl transferases
responsible for the synthesis of hemicellulose in plants, and Novel
glycosyl hydrolases that are able to breakdown cellulosic material for
biofuels production. The candidate will have experience with using
crystallographic methods to study macromolecules; robotic hardware for
performing crystallization trials and imaging trays are available.
Crystals will be characterized and data collected using the beamline
resources of the Berkeley Center for Structural Biology at the
Advanced Light Source.
Essential: Primary duties and responsibilities will include using
robotic hardware to perform screens for crystallization conditions.
Optimization of crystallization conditions. Biophysical
characterization of protein samples using standard techniques, such as
dynamic light scattering. Characterization of crystals using the
Berkeley Center for Structural Biology beamlines at the Advanced Light
Source. Collection and analysis of diffraction data, model building
and structure refinement. Extensive email and verbal interaction with
other researchers. Marginal: Use of small angle X-ray scattering
methods to analyze macromolecular complexes in solution.
Essential: Ph.D. or equivalent in a scientific discipline, preferably
structural biology, biology, or chemistry. Demonstrated experience of
scientific research using crystallographic methods. Experience with
crystallization methods. Solid interpersonal skills and the ability to
work in a team environment are critical. Ability to communicate with a
broad range of researchers. Marginal: Experience with the use of small
angle scattering methods. Familiarity with robotic hardware for
crystal growth.
NOTE: This is a one year Term appointment with the possibility of
renewal under the same terms and conditions, contingent upon continued
funding and availability of work.
Lawrence Berkeley National Laboratory is a world leader in science and
engineering research, with 11 Nobel Prize recipients over the past 75
years, and 59 present members of the National Academy of Sciences.
LBNL conducts unclassified research across a wide range of scientific
disciplines and hosts four national user facilities. AA/ EEO employer
committed to the development of a safe and diverse workforce. Learn
more at http://www.lbl.gov.
For more information about the Center for Protein Folding Machinery
visit: http://proteinfoldingcenter.org/ and the Joint BioEnergy
Institute visit: http://www.jbei.org/. For more information about the
Berkeley Center for Structural Biology visit: http://bcsb.lbl.gov/
To apply: visit http://cjo.lbl.gov/ and search for the job number
21615. Please see http://cjo.lbl.gov/app_instr.html for details of how
to apply.
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Paul Adams
Deputy Division Director, Physical Biosciences Division, Lawrence
Berkeley Lab
Adjunct Professor, Department of Bioengineering, U.C. Berkeley
Vice President for Technology, the Joint BioEnergy Institute
Head, Berkeley Center for Structural Biology
Building 64, Room 248
Tel: 510-486-4225, Fax: 510-486-5909
http://cci.lbl.gov/paul
Lawrence Berkeley Laboratory
1 Cyclotron Road
BLDG 64R0121
Berkeley, CA 94720, USA.
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