Hi Citizens:
I realize this is one of those warranty-violating questions, but is
there a simple way to down-weight figures of merit, or the equivalent
in terms of Hendrickson-Lattman coefficients?
I'm trying to generalize and automate a procedure for solving RNA
structures without heavy-atom phases by feeding phaser random-sequence
model A-form RNA helices. It pretty much works, but there comes a
point where I want to use the phase probability distribution from the
partial/inaccurate model in solvent-flattening while discarding the
model, with the hope of minimizing model bias. The problem is that if
the refinement of the partial/inaccurate model goes reasonably well,
the FOM become inflated to the point where solvent-flattening becomes
less effective for improving and correcting phases.
Thanks.
Bill Scott
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